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After long periods of chronic stress and likely high cortisol my hippocampus has likely seen better days. Sooo I was interested in a short course of tianeptine (as has been discussed previously). I don't have the abstract in front of me, but bacopa apparently protects the hippocampus from cortisol (IIRC) and pregnenelone (thanks funkodyssey):
Pregnenolone sulfate enhances neurogenesis and PSA-NCAM in young and aged hippocampus.
Mayo W, Lemaire V, Malaterre J, Rodriguez JJ, Cayre M, Stewart MG, Kharouby M, Rougon G, Le Moal M, Piazza PV, Abrous DN.
Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U588, Domaine de Carreire, Rue Camille Saint-Saens, 33077 Bordeaux, France.
Age-dependent cognitive impairments have been correlated with functional and structural modifications in the hippocampal formation. In particular, the brain endogenous steroid pregnenolone-sulfate (Preg-S) is a cognitive enhancer whose hippocampal levels have been linked physiologically to cognitive performance in senescent animals. However, the mechanism of its actions remains unknown. Because neurogenesis is sensitive to hormonal influences, we examined the effect of Preg-S on neurogenesis, a novel form of plasticity, in young and old rats. We demonstrate that in vivo infusion of Preg-S stimulates neurogenesis and the expression of the polysialylated forms of NCAM, PSA-NCAM, in the dentate gyrus of 3- and 20-month-old rats. These influences on hippocampal plasticity are mediated by the modulation of the gamma-aminobutyric acid receptor complex A (GABA(A)) receptors present on hippocampal neuroblasts. In vitro, Preg-S stimulates the division of adult-derived spheres suggesting a direct influence on progenitors. These data provide evidence that neurosteroids represent one of the local secreted signals controlling hippocampal neurogenesis. Thus, therapies which stimulate neurosteroidogenesis could preserve hippocampal plasticity and prevent the appearance of age-related cognitive disturbances.
Thoughts on the addition of bacopa and pregnenelone? Any other synergistic supps for this purpose? (NB: I'm not depressed).
Edited by scottl, 29 March 2006 - 12:36 PM.