While they may have something in common, I would not confuse the potential of CNS neurotoxicity with the risk of peripherial neuropathy (esp. documented at high doses). Another problem is that 50-100mg is a very low dose therapeutically speaking and there's no evidence that it would do anything against glycation (AFAIK?) Although, I have not really looked into the issue...
The CNS toxicity is to all appearances from unconverted pyridoxine acting as a B6 antagonist. The full text says that
These changes were more typical for the experimental group receiving excess vitamin B6 intake for a long period (20 days) and, paradoxically, they are reminiscent of those resulting from vitamin B6 deficiency in rats [27].
100 mg/day pyridoxamine worked as well as 500 mg/day
here. It's still available from overseas, so I don't see a reason to settle for PLP. 100 mg/day PM should convert to PLP well (unlike the 600 mg/kg/day that was used to establish the superiority of PLP over PM), so you should get the benefits of both of their mechanisms. I take it with my nuts and meat on the off chance that it scavenges dietary AGEs like its fellow amine aminoguanidine does (PMID: 10342821).
I target a selenium level just above
130 ng/ml. My dose-response curve is 200 mcg daily = 150 ng/ml, 200 mcg 6 days a week = 124 ng/ml, and 200 mcg 13 days per fortnight = 134 ng/ml.
