4 replies to this topic

[enoch1]

Hi All,

I've just started using lithium orotate 5mg, haven't notice anything at the moment. Should I bump my dosage to 15mg ? I've used 10mg havent noticed much.
What dosage is used for the neurogenesis and grey matter increase dosage ?


Thanks in advance

[Cephalon]

Hi Enoch1

You are just going to use Lithium for it's neuroprotective effects and neurogenisis as you said, but not for healing of an medical condition, correct?

I would not suggest to go up to 15mg. You may try 5mg morning and evening as some do.

I myself only use 1mg before bed for nutritional reasons (see Michaels inspiring post: here for reasons)

Anything above 1mg makes me sick (stomach & head)

[enoch1]

Thanks, correct I don't need it to treat a condition just for the neuro benefits so a quater is effective enough for you ?. But, I'm trying to find the studies that claim of the neuro benefits grey matter increase what dosage is it high ?

Also is 125mg of lithium orotate equivalent to 5mg of elemental lithium ?

Edited by enoch1, 14 May 2011 - 02:32 PM.

[Cephalon]

Hi Enoch1,

Correct, 125 mg lithium orotate yield 5 mg elemental lithium.

Unfortunately I do not know what the dose for neuroprotection/ BDNF increase is. In literatur the BDNF increase is often reportet in doses used for mood stabilization, which are quite high.


I'm sure someone on this board will know!


Lithium is supposed to work through inhibition of GSK-3 beta.

A molecular mechanism for the effect of lithium on development.Klein PS, Melton DA.
Source
Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia 19104, USA.


AbstractLithium, one of the most effective drugs for the treatment of bipolar (manic-depressive) disorder, also has dramatic effects on morphogenesis in the early development of numerous organisms. How lithium exerts these diverse effects is unclear, but the favored hypothesis is that lithium acts through inhibition of inositol monophosphatase (IMPase). We show here that complete inhibition of IMPase has no effect on the morphogenesis of Xenopus embryos and present a different hypothesis to explain the broad action of lithium. Our results suggest that lithium acts through inhibition of glycogen synthase kinase-3 beta (GSK-3 beta), which regulates cell fate determination in diverse organisms including Dictyostelium, Drosophila, and Xenopus. Lithium potently inhibits GSK-3 beta activity (Ki = 2 mM), but is not a general inhibitor of other protein kinases. In support of this hypothesis, lithium treatment phenocopies loss of GSK-3 beta function in Xenopus and Dictyostelium. These observations help explain the effect of lithium on cell-fate determination and could provide insights into the pathogenesis and treatment of bipolar disorder.

http://www.ncbi.nlm....pubmed/10320030




http://en.wikipedia....nthase_kinase_3

http://en.wikipedia.org/wiki/GSK3B

[enoch1]

Awesome thanx