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8,935 views
microglia therapy
As for the effect the transplanted microglia have on the pathology: I do not see a big difference in the amount of amyloid in the Alzheimer mouse brain without cells (A) and with microglia transplanted (B). So we have to wait until we get all brains analysed by sterology for the exact amyloid quantification. 
Hi again,
To visualize microglia and amyloid plaques in vivo, we established different staining protocols (including histology and immunohistology) to later evaluate microglia number after transplantation and also amyloid load. Top left is showing an immuno staining for amyloid and top right is an overview for microglia in the...
We used several markers to prove that what looks like microglia really are microglia. We used so called surface markers (CDs) including CD11b and CD45. These markers are also used to distinguish between what people all macrophages and what people think microglia are (there are a lot of discussions about the identity of microglia). The cells in the red...
To start with the microglia replacement therapy we need lots of cells and they must resemble the original microglia. In the pictures you see microglia isolated from mice (left) or self-made microglia derived from bone marrow (in vitro differentiated).
As a reminder WHY we are doing this:
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4,556 views
microglia, stem cells, therapy and 1 more...
In 2011, the Longecity community raised money to support a research project on microglia stem cell therapy. Over the next few days, we will be reporting interim results in this blog.
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