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What supplements influence cortisol levels?

Posted by dumbbellina , 28 May 2009 · 4,102 views

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Asperger syndrome information

Upon awakening, there is normally a surge in cortisol, a steroid hormone produced by the adrenal gland and released in response to stress. This response is absent in adolescent boys with Asperger syndrome, which may explain some of the symptoms of the condition, such as the need for routine and resistance to change. Among other functions, the ability to adapt to change is controlled by the hypothalamic-pituitary-adrenal axis, which controls the dramatic increase in cortisol upon awakening, referred to as "the cortisol awakening response." The cortisol awakening response is a robust and reproducible neuroendocrine phenomenon which has been positively correlated with psychological and physical well-being. Dr. Mark Brosnan from University of Bath and colleagues say their research points to a lack of response in the hypothalamic-pituitary-adrenal axis in individuals with Asperger syndrome, which may help explain why these individuals have difficulties if there are minor changes in their routine or environment. In the study, the investigators measured the cortisol in saliva of 20 adolescent males with Asperger syndrome and 18 age-matched controls at the time of awakening and 30 minutes later. While a significant cortisol awakening response was clearly evident in the control group, this was not the case in the Asperger group. Psychoneuroendocrinology 2009.

Cortisol and DHEA
Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study.
Psychopharmacology (Berl). 2005 Oct 18;:1-11 Psychobiology Research Group, School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
Dehydroepiandrosterone (DHEA) has been reported to enhance cognition in rodents, although there are inconsistent findings in humans. Twenty-four healthy young men were treated with a 7-day course of oral DHEA (150 mg b.d.) or placebo in a double blind, random, crossover and balanced order design. Subjective mood and memory were measured using visual analogue scales (VASs). Cortisol concentrations were measured in saliva samples. ERPs were recorded during retrieval in an episodic memory test. Low-resolution brain electromagnetic tomography (LORETA) was used to identify brain regions involved in the cognitive task. DHEA administration led to a reduction in evening cortisol concentrations and improved VAS mood and memory. DHEA treatment improved memory recollection and mood and decreased trough cortisol levels. The effect of DHEA appears to be via neuronal recruitment of the steroid sensitive ACC that may be involved in pre-hippocampal memory processing. These findings are distinctive, being the first to show such beneficial effects of DHEA on memory in healthy young men.


Cortisol and 5-HTP

L-5-hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers.
Psychopharmacology (Berl). 2002 Jun;161(4):365-9.
Department of Psychiatry, Institute of Brain and Behaviour, Maastricht University, AB Maastricht The Netherlands
Hypersensitivity of brain serotonin receptors has been proposed as a causal mechanism in the pathophysiology of panic disorder. This theory can be tested, using serotonergic stimulation of the HPA axis. Up to now, plasma cortisol has generally been used as the outcome measure in such studies. Assessment of salivary cortisol is a non-invasive alternative to measure HPA axis activity. Salivary cortisol levels were measured in 24 panic disorder patients and 24 healthy volunteers, following ingestion of 200 mg L-5-hydroxytryptophan or placebo. A significant rise in cortisol was observed in both patients and controls following ingestion of L-5-hydroxytryptophan. No such effects were seen in the placebo condition. The results show that L-5-hydroxytryptophan stimulated salivary cortisol is a useful probe of serotonin function in healthy volunteers as well as panic disorder patients, and provide some evidence against a serotonin receptor hypersensitivity in panic disorder.


Vitamin C and cortisol
A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress.
Psychopharmacology (Berl). 2002 January. Brody S, Preut R, Schommer K, Sch�rmeyer TH. Center for psychomatic and Psychobiological Research, University of Trier, Trier, Germany.
Physiological responses to stress are considered disruptive to health. High-dose ascorbic acid has reduced indices of stress in laboratory animals. We conducted a randomized double-blind, placebo-controlled 14-day trial of sustained-release ascorbic acid (60 healthy young adults; 3 x1000 mg/day Cetebe) and placebo (60 healthy young adults) for reduction of blood pressure, cortisol, and subjective response to acute psychological stress (Trier Social Stress Test, TSST, consisting of public speaking and mental arithmetic). Six subjects from each group were excluded. Compared to the placebo group, the ascorbic acid group had less systolic blood pressure (an increase of 23 versus 31 mmHg), diastolic blood pressure, and subjective stress responses to the TSST; and also had faster salivary cortisol recovery (but not smaller overall cortisol response). Cortisol response to 1 microg ACTH, and reported side-effects during the trial did not differ between groups. Plasma ascorbic acid level at the end of the trial but not pre-trial was associated with reduced stress reactivity of systolic blood pressure, diastolic blood pressure, and subjective stress, and with greater salivary cortisol recovery. Treatment with high-dose sustained-release ascorbic acid palliates blood pressure, cortisol, and subjective response to acute psychological stress. These effects are not attributable to modification of adrenal responsiveness.





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