The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.
Figure 1
Factors, Modulators, and Executers of Carbohydrate-Mediated Healthspan Regulation
(A) Physiological and environmental factors that may regulate healthspan in relation to carbohydrate uptake or glucose catabolism.
(B) Therapeutic modulators of the individual factors depicted above.
© Selected mechanistic regulators that cumulatively mediate the downstream execution of (A) and (B), respectively.
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