Just a quick addition, since people seem to be chronicling their joint/tendon pain as related to resveratrol. This summer and fall I was playing a lot of tennis and got a bad case of tennis elbow, the first I have had in my entire life. At the time I was taking between 700 - 1200 mg of Resveratrol. Note that I am 29 years old and in excellent physical condition and have had no other musculoskeletal or joint issues before (aside from mild scoliosis which is a structural issue and not related).
Since this Winter I have been taking between 2000 and 2700 mg per day. Currently 1/5th of my daily dosage is from BAC 50% Resveratrol and 4/5th of my daily dosage is from Mega-Res 99% product. I now take Res 3 times a day, but I only make the "ghetto SIRT-501" in the morning . At present I have no joint/tendon pain but then again it has been too cold to play much tennis. (I still workout at least 4 times a week, weights, running and gym cardio) which during the summer and fall I was doing on top of playing a lot of tennis.
So, maybe it was just the fact that I was playing a lot of tennis, hitting the ball harder or whatever and not the Resveratrol. Thats the problem with anecdotal evidence, there are so many variables unaccounted for. Note also that my endurance and strength has gone up dramatically in the past year and maybe I am just able to play more tennis and thus overuse injuries are perhaps more likely. Annectdotaly my increase in fitness could be in part attributed to Resveratrol or any number of other supplements that I have added in the past year. Again anecdotal.
Does anyone know the dosing schedules (qd, bid, tid, qid) for the Sirtis studies offhand, I'm sure I could dig around and find something but I'm being lazy. The last I looked at the Res forums, our collective consensus was that what was needed was first a large enough single dose to ensure blood levels and overcome absorption and metabolism issues and as long as the single dosage were large enough then taking multiple doses per day was good to ensure a more constant blood level?
Edited by edward, 13 January 2008 - 06:39 PM.