scottknl, on 01 January 2012 - 06:03 AM, said:
BMI means something. Everyone with high BMI is dead before they hit 100. Lowish BMI is best for longevity.
While I'd agree that a low-normal BMI is associated with a higher chance of exceptional survival in the general population,(eg. (1)) it is certainly not the case that "Everyone with high BMI is dead before they hit 100," and the lecture slides you link neither prove, nor even assert, that overweight is an absolute barrier to cent-ship. Certainly at least some people clearly do
survive to currently exceptional ages -- for instance, in this population of Ashkenazi Jews with "longevity genes," "People with exceptional longevity had similar mean body mass index (men, 25.4±2.8 kg/m2 vs 25.6±4.0 kg/m2, P=.63; women, 25.0±3.5 kg/m2 vs 24.9±5.4 kg/m2; P=.90) ... as the NHANES I population," and 47.8% of men and 43.8% of women in that group had had a BMI ≥25 at some point in their lives
Thomas Perls, of the New England Centenarian Study, who is looking at genetic centenarians from a more diverse group of families, has informally reported that "I haven't ever seen an obese centenarian male... but a number of women get away with looking like the queen mum."
Again,low-normal lifelong BMI is associated with greater longevity the general population, thought I would add that IAC, absolute BMI per se has nothing to do with the effects of CR.
1: Willcox BJ, He Q, Chen R, Yano K, Masaki KH, Grove JS, Donlon TA, Willcox DC,
Curb JD. Midlife risk factors and healthy survival in men. JAMA. 2006 Nov
15;296(19):2343-50. PubMed PMID: 17105797.
2: Rajpathak SN, Liu Y, Ben-David O, Reddy S, Atzmon G, Crandall J, Barzilai N.
Lifestyle factors of people with exceptional longevity. J Am Geriatr Soc. 2011
Aug;59(8):1509-12. doi: 10.1111/j.1532-5415.2011.03498.x. Epub 2011 Aug 3. PubMed
Edited by Michael, 01 January 2012 - 03:02 PM.