Cognitivespeed, on 12-May 2008, 07:39 PM, said:
edward, on 12-May 2008, 07:36 PM, said:
Supposedly most of the L-Carnosine (a di-peptide of beta-alanine and histidine) is broken down into beta-alanine and histidine in the digestive tract. The small amount of L-Carnosine that does escape this is broken down by carnosinase to once again beta-alanine and histidine. So the only way to overcome this is to take whopping doses.
Beta-Alanine is the rate limiting factor in the synthesis of L-Carnosine (unless you are on a low protein diet you have enough histidine) and Beta-Alanine supplementation has been shown to after chronic supplementation to boost L-Carnosine levels in muscle tissue by an amazing 80%. Granted this is muscle tissue but it stands to reason that the same is true in other areas of the body as well.
Any links to support your above statements as fact?
"the Harris study" the abstract mentions 65% increase in muscle carnosine after 4 weeks I can't read the pdf but from another source the total increase after 10-12 weeks was 80%
Good summary here even though these people have a commercial interest. Their references seem to be in order. Besides this is not new info, many people on this board have mentioned the same sorts of thing, and many people on here take Beta-Alanine instead of Carnosine
the references for the above page found at the bottom of the page
Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J. (2006) Effect of Creatine and ί-Alanine Supplementation on Performance and Endocrine Responses in Strength/Power Athletes. IJSNEM, 16(4).
Zoeller RF, Stout JR, O'kroy JA, Torok DJ, Mielke M.(2006)
Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion. Amino Acids, 1-6
Harris RC, Tallon MJ Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JA (2006) The absorption of orally supplied §-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids, March
Harris RC, Ponte J, Sale C, Jones GA, Kim HJ, Wise JA. Effect of 14 and 28 days B-Alanine(Carnosyn) supplementation on isometric endurance of the knee extensors.Univeristy of Chichester, Chichester UK; Korea National Sport Univeristy, Seoul Korea. Poster Presentation
Harris RC, Marlin DJ, Dunnett M, Snow DH, Hultman E ((1990) Muscle buffering capacity & dipeptide content in the thoroughbred horse, greyhound dog & man. Comparative Biochem Physiol 97A: 249-251
Harris, R C.; Hill, C; Wise, J A.(2003) Effect of combined Beta-Alanine and creatine monohydrate supplementation on exercise performance.Medicine & Science in Sports & Exercise:Volume 35(5) Supplement 1May 2003p S218
Harris RC, Dunnett M, Greenhaff PL(1998) Carnosine & Taurine contents in individual fibers in human vastus lateralis muscles. J Sports Sci 16: 639-643.
Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA (2006) Influence of b- alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity Amino Acids.
Hill C. A., R. C. Harris, H. J. Kim, L. Boobis, C. Sale, J. A. Wise. "The effect of beta-alanine and creatine monohydrate supplementation on muscle composition and exercise performance." (Presented at the American College of Sports Medicine Annual conference, 2005, Nashville.)
Kim HJ, Kim CK, Lee YW, Harris RC, Sale C, Harris DB, and Wise JA (2006) The effect of a supplement containing β-alanine on muscle carnosine synthesis and exercise capacity, during 12 wk combined endurance and weight training. J. Inter. Soc. Sports Nutr. 3(1): S9
Stout JR, Cramer JT, Mielke M, O'Kroy J, Torok D, and Zoeller RF (2006) Effects of 28 days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold J Strength Cond Res (in press)
Stout JR, Cramer JT, Zoeller RF, Torok D, Costa P, Hoffman JR (2006) Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino Acids. Nov 30
Suzuki Y, Ito O, Takahashi H, Takamatsu K (2004) The effect of sprint training on skeletal muscle carnosine in humans. Intl J Sport Health Sci 2: 105-110.
Suzuki Y, Ito O, Mukai N, Takahashi H, Takamatsu K (2002) High Level of Skeletal Muscle Carnosine Contributes to the Latter Half of Exercise Performance during 30-s Maximal Cycle Ergometer Sprinting. Jpn J Physiol 52:199-205.
Bate-Smith EC (1938) The buffering of muscle in rigor: protein, phosphate and carnosine. J Physiol 92: 336- 343,1938.
Gulewitsch W, Amiradzibi S. Uber das carnosine, eine neue organische Bases des Fleischextraktes, Ber Disch Ges 1900; 33:1902-4.
Barger G, Tutin F. Carnosine, constitution and synthesis. Biochem J 1918; 12: 4