In a study of people with dementia, the stimulation of NGF over 6 months created improvements in perceptual capacities as well as well as an increase in the Functional Independence Measure (FIM), which is a measure of independence in physical capabilities (eating, dressing, walking, etc.) and in perceptual capacities (understanding, communication, memory, etc.).
This seems to suggest that NGF produces global improvements in brain function.
That study was conducted with Lion's Mane.
In addition to Lion's Mane, Ashitaba and idebenone stimulate production of NGF. http://www.organicas...ervegrowth.html
Looking to maximize this effect, I also take Acetyl L Carnitine, which multiplies the effect of NGF by 100 apparently. I think the mechanism of action is increasing the number of NGF receptor sites.
Along these same lines, I am thinking about taking Acetyl L Carnitine Arginate.
From the same article:
Although not a stimulator of NGF, ashwagandha promotes regeneration of axons and dendrites.
In another study at the same institute, researchers found that ashwagandha helped support the growth of nerve cell dendrites, which allow these cells to receive communications from other cells. This finding suggests that ashwagandha could help heal the brain tissue changes that accompany dementia.
Finally, in a third published study, the researchers noted that ashwagandha helped promote the growth of both normal and damaged nerve cells, suggesting that the herb may boost healthy brain cell function as well as benefit diseased nerve cells.
Do you think, over time, that everyone will see the same effect as those seen for dementia patients? Or will the production of axons, dendrites, and new nerve cells be unnoticeable?
Can you think of any adverse consequences to revving up the production of NGF over extended periods of time? Given that the body is a homeostatic system and that the natural levels of NGF probably serve some purpose, there must be some sort of drawback to stimulating NGF over a period of years, which is what I'm planning to do.
Edited by bmud, 28 January 2010 - 05:34 PM.