Does it seem like I have some huge beef with uridine? I'll probably give it a try sometime soon, though the questions about interaction with nucleotide pools will probably mean I'll be comfortable with other options in the long-term.
I'm glad it works great for you, but you're maybe the second or third person I've seen who's said so. I try to cultivate a realistic understanding when I read about something, and I'm sorry if me not being carried away with enthusiasm is ruining anyone's opinion of this unfairly. But I don't see why my comment in this thread should raise any eyebrows. Uridine is not a universal nootropic as far as I'm aware, however enthusiastic a few people might be about it.
chrono, on 22 November 2011 - 02:15 AM, said:
I think some people (probably the ones who are most enthusiastic about the substance) are taking uridine along with something like alpha GPC, which can have strong nootropic effects on its own. I think the people who find this to be a subjectively noticeable nootropic are probably a small minority.
Just to clarify, I didn't mean to imply that it's not capable of producing any nootropic effect. If nothing else, it can be converted to CDP-choline in the brain, and it has an effect on dopamine as well (and perhaps others). It's hard to say if neurogenesis should really 'feel' like anything, but it probably depends.
I was mostly going on the fact that it's been discussed here for several years, and there seem to be only a few people so far who have had much to say about the experience. Hopefully it's more effective with better products, or cosupplementation, and more reports of benefits will accumulate if more people take it.
As far as brewer's yeast goes, I think that the uridine (and the other nucleotides) is bound within peptide structures. But I'm not too sure of that, in advance of reading a few full studies. This could either mean that the peptide in question is easily cleaved away in the stomach or plasma (as many peptides are), or that it remains bound and doesn't act the same as free uridine.
Wikipedia suggests it's 3% uridine content, so 30g should be giving you about 1g uridine.
Edited by chrono, 22 November 2011 - 09:42 AM.