4 replies to this topic

[topsykretts]

Can anyone think of any nootropics that would restore acetylcholine receptor levels after chronic acetylcholinesterase inihbitor usage (huperzine A for example)?

[malden]

I think if there is no underying cause, it will come back to normal. (homeostatis)

Exersize will help a good homeostatis.
mayby some basic things like omega 3 ginkgo idebenone vitamin e uridine could help speed up the healing proces.

on the other hand, if the problems are creatid as a side effects of regulal medicine (like AD) things kan be a lot difecultier to restore.

why do you think there is a prolem on theacetylcholine receptor , and what exactly have you use?

[zodiac]

Not to beat a dead horse around if it's already way over-discussed on imminst, but AFAIK, the racetams (namely piracetam) actually function to upregulate ACh.. at least certain muscarinic receptors. Look into this further if you wish.. I'm a bit pressed for time to cite or link truly relevant sources, but was hoping to give you at least a starting point.

Best,
-z

[SuperjackDid_]

Any possible if Piracetam cause upregulate ACh beyond normal level and cause overstimulation ?

[gamesguru]

Time and consistency will bring homeostasis back. Huperzine desensitization isn't bad unless you really abuse it >200 mcg daily. I wouldn't recommend experimenting, as you could just exacerbate symptoms. Unless the symptoms are intolerable, just wait it out.

I don't know of any papers which demonstrate a mechanism through which piracetam upregulates ACh receptors...most of them deal with its effect on acetylcholine metabolism...not receptor metabolism. If someone can find a study linking ACh receptors and piracetam, please share.

At least one study documents that piracetam causes harm above 400 mg/kg (http://www.ncbi.nlm....pubmed/10834086). This is probably due to metabolism of acetylcholine, not due to an over-production of AChRs. There are some puzzling effects, choline increasing or decreasing, or acetylcholine increasing or decreasing (though no mention of intracellular measurements are made in the abstract): http://www.ncbi.nlm..../pubmed/7301036.

Not to give you crazy ideas, but...
Citocholine might upregulate ACh receptors, but it's only demonstrated to do so consisently with dopamine receptors (http://www.ncbi.nlm....les/PMC1908237/& http://stroke.ahajou...7/1931.abstract)

Genistein appears to upregulate certain ACh receptors (http://www.jneurosci...25/14/3712.full), but I wouldn't go abusing it based on this one study.
Support for this theory comes from: http://www.ncbi.nlm..../pubmed/1382118 & http://jp.physoc.org..._1/175.full.pdf.

Edited by dasheenster, 25 July 2012 - 02:20 AM.