Well a few thoughts on longevity yogurt
you can make as much as you like just with moving a starter culture thus this supplement only requires getting once. It would be nice to visiblize it though, I wonder if bacteria are light polarizable genetically, that way you could verify the concentration at feces without going fluorescent. I wonder if yogurt people sometimes add more sugar to their probiotic yogurt to grow an even higher number of beneficial bacteria. If this LKM512 had GFP then you could see if adding sugar upped the color thus the activity level.
When I wrote about possible variants of spermidine I did not describe halogenated spermidine. Halogenation frequently makes pharmaceutical molecules 10 to 100 or even 700 times stronger possible (compare cortisol to fluorocort) changing the dose to just 2 or 3 milligrams. Also the length of the alkane could be varied, or the molecule attached to another molecule that makes it particularly good at passing ion channels or concentrating at particular tissues. These are public domain ideas. An actual drug researcher could still get a patent based on precisely which atom location is halogenated or the specific length of the variant alkane.
Further, that superexpression of spermidine at transgenic mice actually goes back to 1991-1993 makes me think a particular longevity grant could occurTo benefit humanity a fund could be created where any lab experiment where the treated mammals lived 20 pct longer than the untreated group automatically received funding to continue the experiment until the natural death of all the organisms
as well as provide supplemental funds to keep an image like video record of the physiological variation amongst the groups. That genetically modified superproducers of spermidine were first created at 1991-93 yet the longevity effect only noticed during 2011 suggests value to gathering full data.
Noting the LKM512 fed mice lived more than twice as long It is possible a continuous video record would show different age at hair whitening as well as rate of hair whitening, measuring the similarity of these curves between spermidine n LKM512 would provide greater numeric support for similar mechanism of chemical action between spermidine n LKM512
Also camera placement provides different data that differing researchers may value. a highly placed camera could record longer retention of original hair color as well as rapidity or gradualness of motion yet a mouse level camera could better detect reduction of cancer as well as mammary cancer thus providing different groups with very valuable data
As the FDA has approved latisse It is possible the demonstrating sperimidine or a variant that changes the start or rate of the whitening of hair could be approved particularly as it also reduces cancer as well as longevizes lab mammals. The observations of actual rate of change of human hair remaining its natural color longer could be fairly rapid.I have this idea that if the LKM512 researchers reviewed their data with a different mathematical technique they could find a p ratio as to the amount of longevity from spermidine at the 512LKM512 yogurt group.
Possibly they would measure the mg/kg of spermidine present at the yogurt, then attribute the multiplied amplitude of the longevity of the actual spermidine only curve to just spermidine. This could be used to provide two new P values from the data the P number from nonspermidine yogurt ingeredients as well as a kind of metaanalysis P number for all spermidine content from both groups. If using a well described math technique that P value on two treatments, each with spermidine may have a more accurate P number than the spermidine alone group.
Kind of like if we gave two groups of mice Honeydew melon with deprenyl, as well as another group of mice just deprenyl.
The deprenyl alone group lived 27 pct longer. They honeydew melon with depreneyl group lived 33 pct longer. Each mouse received .05 mg/kg at the deprenyl only group, they honeydew melon with deprenyl group received .07 mg/kg deprenyl along with the honeydew melon.
calculate the P value of the effect of .05 .06 as well as .07 on the population. I have seen a similar mathematical effect used on the effect of DHA at breastmilk possibly at the actual text of this study http://www.ncbi.nlm....pubmed/15499945
Edited by treonsverdery, 28 February 2012 - 02:06 AM.