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Effects of resveratrol on sleep pattern in the mouse lemur

resveratrol in vivo sleep

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#1 malbecman

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Posted 12 March 2012 - 03:59 PM


I can't get access to the full text so it's difficult to evaluate this one but just wanted to put it out there...


Chronobiol Int. 2012 Apr;29(3):261-70.
Effects of Dietary Resveratrol on the Sleep-Wake Cycle in the Non-Human Primate Gray Mouse Lemur (Microcebus murinus)*.

Pifferi F, Rahman A, Languille S, Auffret A, Babiloni C, Blin O, Lamberty Y, Richardson JC, Aujard F.

UMR CNRS-MNHN 7179, Brunoy , France.
Abstract

Converging evidence shows that the non-human primate gray mouse lemur (Microcebus murinus) is ideal for the study of the aging process and for testing the effects of new therapies and dietary interventions on age-associated pathologies. One such dietary supplement is resveratrol (RSV), a dietary polyphenolic compound with several positive effects on metabolic functions and longevity. However, little is known about the effect of RSV on the lemur sleep-wake cycle, which reflects mammalian brain function and health. In the present study, the authors investigated this effect by comparing sleep-wake cycles in adult lemurs based on electroencephalographic (EEG) rhythms. The effect of short-term RSV supplementation on the sleep-wake cycle of mouse lemurs was evaluated in entrained conditions (long-day photoperiods, light:dark 14:10). After 3 wks of RSV supplementation, the animals exhibited a significantly increased proportion of active-wake time, occurring mainly during the resting phase of the sleep-wake cycle (+163%). The increase in active-wake time with RSV supplementation was accompanied by a significant reduction of both paradoxical sleep (-95%) and slow-wave sleep (-38%). These changes mainly occurred during the resting phase of the sleep-wake cycle (RSV supplementation induced negligible changes in active-wake time during the active phase of the sleep-wake cycle). The present data suggest that RSV may be a potent regulator of sleep-wake rhythms and could be of major interest in the study of sleep perturbations associated with aging and neuropathology. (Author correspondence: aujard@mnhn.fr ). PMID: 22390239
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#2 Mind

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Posted 12 March 2012 - 05:32 PM

Just trying to read this correctly. The monkeys slept less because of RSV (and there was no observed changes during the time they were awake?)

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#3 maxwatt

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Posted 12 March 2012 - 05:55 PM

We know from earlier studies that resveratrol activates genes which regulate the sleep-wake cycle. There have been complaints by some users that resveratrol interferes with sleep, and taking it in the morning rather than at nght seems to eliminate such insomnia.



1.


Resveratrol dietary supplementation shortens the free-running circadian period and decreases body temperature in a prosimian primate.

Pifferi F, Dal-Pan A, Menaker M, Aujard F.

J Biol Rhythms. 2011 Jun;26(3):271-5.


PMID: 21628554 [PubMed - indexed for MEDLINE]


http://www.ncbi.nlm....pubmed/21628554



2.


Resveratrol regulates circadian clock genes in Rat-1 fibroblast cells.


Oike H, Kobori M.

Biosci Biotechnol Biochem. 2008 Nov;72(11):3038-40. Epub 2008 Nov 7.


PMID: 18997419 [PubMed - indexed for MEDLINE] Free Article


http://www.ncbi.nlm....pubmed/18997419

Resveratrol regulates circadian clock genes in Rat-1 fibroblast cells.



Oike H, Kobori M.

Biosci Biotechnol Biochem. 2008 Nov;72(11):3038-40. Epub 2008 Nov 7.



PMID: 18997419 [PubMed - indexed for MEDLINE] Free Article


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