3 replies to this topic

[treonsverdery]

Ovolin a possible happiness drug made from a common enzyme with egg whites

trypsin http://www.amazon.co...sl_3k1evavzxa_e an ezyme apparently naturally creates anxiolytix peptides from egg whites. http://www.ncbi.nlm....pubmed/22564055

If anybody would like to Make some then describe here what cognitive effects this possible recreational peptide drug has it would be wonderful.

We found that tryptic digest of ovalbumin after oral (p.o.) and intraperitoneal (i.p.) administration exhibits anxiolytic-like activity in mice, and then searched orally active low-molecular-weight peptides with anxiolytic-like activity in the tryptic digest. Val-Tyr-Leu-Pro-Arg, named ovolin, corresponding to ovalbumin (281-285), mimicked the anxiolytic-like activity after p.o. and i.p. administration.

One fascinating thing about this is that it is orally active. That suggests that the Val-Tyr-Leu-Pro-Arg sequence could be modified or attached to other peptides to create greater oral bioavailability

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[meatsauce]

Can you find out more about the dosage?

[niner]

Can you find out more about the dosage?

Someone will have to chase down the full text of the paper linked in the first post. Egg whites are 60-65% ovalbumin, so you might be able to get by with trypsinizing the whole egg white, assuming it doesn't contain a trypsin inhibitor, which it might. Just eating eggs and taking digestive enzymes probably isn't going to cut it. Even if you did it 100% right, it still might not work in humans, since we aren't mice...

[etizsupplyusa.com]

Can you find out more about the dosage?

Someone will have to chase down the full text of the paper linked in the first post. Egg whites are 60-65% ovalbumin, so you might be able to get by with trypsinizing the whole egg white, assuming it doesn't contain a trypsin inhibitor, which it might. Just eating eggs and taking digestive enzymes probably isn't going to cut it. Even if you did it 100% right, it still might not work in humans, since we aren't mice...

You are thinking of the wrong compound . Ovalbumin is a storage protein that can be used to treat heavy metal poisoning by trapping the heavy metal ions with the sulfhydryl bonds on the protein.

Ovolin merely showed anxyiolic action in mice, which interestingly enough was inhibited by cox inhibitors (think aspirin, tylenol, etc).

Interesting finding nevertheless, but I doubt it will be anything more than something to study, it would surprise me if it was commercialized.

Sincerely-


Bill at etizchemusa.com


edit: I only read the title before responding, is this saying that ovolin will possibly potentate ovalbumin via acting on similar pathways? Sorry for the skim reading lol I didn't mean to sound like an a-hole

Edited by MolecularEuphoria, 04 November 2013 - 01:03 AM.