I've become convinced that TNF is a critical piece of the puzzle for understanding Human Longevity, Morbidity, and Mortality.
I began more seriously considering the role of Tumor Necrosis Factor (TNF) in Longevity, Morbidity, and Mortality as a result of participating in the Buckyballs in Olive Oil double lifespan of Wistar Rats thread. I had earlier become familiar with TNF as a result of a long time spent doing research on the 5-Lipoxygenase (aka, 5-LO or 5-LOX) Inflammatory Pathway, but I hadn’t looked at it specifically with Longevity in mind.
I hadn’t realized how much evidence, explicit and implicit (through multiple study comparison), exists about the importance of TNF. I’ll bet you haven’t either. If more people knew about this evidence, someone would have established a Longecity thread about it long ago. But they haven't and, in fact, they couldn't, because the evidence has only recently become clear enough to see...
The objective here, then, is to establish a Forum Thread to post about, discuss, and debate research related to Tumor Necrosis Factor. Let me be clear. I’m just learning about it myself, but I've learned enough to want to become an expert about it. Maybe you will too.
I’m kicking this thread off by providing multiple layers of evidence showing how critical TNF is to Longevity, Morbidity, and Mortality, including, relatively soon, at least...
- gene related evidence
- Extreme Longevity study evidence
- evidence related to the 5-LO Inflammatory Cascade literature
- Cholinergic Anti-Inflammatory Pathway evidence
- insulin resistance study evidence
- tumor study evidence
- and others TBD
TNF Background Information
http://en.wikipedia....necrosis_factor (notice a change of name)
The Paradoxical Role of TNF for Health
A fundamental point about TNF is that it plays a positive role in health through its activation by the Immune System. But it is an Inflammatory Cytokine also so that, once its role in attacking invaders has been accomplished, it becomes a negative factor in health because it attacks tissue. TNF activation is among the most important elements driving the diseases that kill most of us off these days, what are now called Auto-Immune Diseases.
Here’s a study abstract about this paradoxical role...