If the production of ROS is protective against viruses and cancer, could putting C60 into the mitochondrial membrane and quenching the ROS cause problems? I know that the one rat study seemed to indicate the reverse, but if the ROS is actually protective, how would quenching them be other than non-protective?
This is my main concern. C60 seems a lot like glisodin to me, in that regard. I'd like to see evidence that C60 doesn't shutdown endogenous antioxidant levels. I think taking C60 effectively means you are on this product for life, because it becomes your body will become trained to different levels of ROS now that C60 is quenching a lot of this behavior.
And without knowing the correct human dosage, it may make it a very calculated risk as to what is the right amount over an extended period of time.
As I mentioned above, I'm not worried about viruses or cancer, but like you I'm concerned about the effect of c60 on endogenous antioxidant levels. Because biology is so strongly homeostatic, I'd be surprised if endogenous antioxidants were not down-regulated to some extent. I don't think it means that you're stuck on it for life. You would just have a few days of oxidative stress while your endogenous systems came back up. I would liken this to my experience of stopping NR after 3 or 4 months-- I was tired for a few days but felt pretty normal in short order.
I'm not sure that there even is a correct human dosage. I think it's more likely that there are a range of dosages that work. Different people no doubt have different optimum dosage, depending on whatever dysfunction they do or do not have. My main concern is how much is too much.