3 replies to this topic

[treonsverdery]

It occured to me that a number of known longevity producing drugs could have been rapidly found as a result of creating brain homogenates (blenderizing brains) then dividing the homegenates according to lipophilicity or hydophilicity, then dividing them on mass with a colloid gradient, then feeding them to baby mice.

DHA, choline, phosphatidylserine, general RNA could have all been found rapidly this way, so perhaps actually doing this then seeing what the various molecular mass fractions of brain homogenates do when fed to mice will find new longevity drugs as well as new physiology of longevity as well as cognition.

I suggest  that the mice be fed homogenates of high functioning brains
octopus, parrot, mink, bee, as well as voluntary human donations.   Creating cytoplasmic as well as lipid portions,  also noting that some brains are 85 pct glia, 15 pct neurons, homogenates from each of glia as well as neurons.  It is possible that the blood brain barrier, which is notable as it causes neurons as well as glia to live much longer than unfiltered body tissues, could also be homogenized then mass sorted, then fed to mice to find beneficial effects.  what if the bbb is more than a filter, perhaps it also secretes near area cytokines or growth factors.  blenderizing then feeding is a way to test this.

5 species
3 tissue types
2 lipophilicities
7 different mass sizes from a colloid gradient
is 210 different brain homeganetes to feed baby mice

if the baby mice  show beneficial effect on cognition during the first 60 days with any of the 210 variations as they have been published to with choline, DHA then new cognition as well as possibly longevity drugs have been found.  (longevity drugs as nootropics have a strong co function with longevity drugs)

A further possibility is to place the lipid or water soluble portions at an enteric form so as to create GI tract absorptionto emphasize effect.

at .59 per mouse http://www.vetmed.ws...iemFY11-12.xlsx , 10 mice per brain homegenate, thats 5.90 *60 * 210    $74,340  to likely find a number of bioproduct nootropics (pre FDA appoved as these are natural products) as well as find a number of harmful natural materials that humans can learn to avoid. It is possible this might be less than $10,000 overseas


It could be finding really new naturally occuring chemicals from brain homogenates will direct researchers to new aging theories as well.

Edited by treonsverdery, 16 July 2012 - 05:50 PM.

[niner]

treonsverdery, on 16 July 2012 - 05:48 PM, said:

at .59 per mouse http://www.vetmed.ws...iemFY11-12.xlsx , 10 mice per brain homegenate, thats 5.90 *60 * 210    $74,340  to likely find a number of bioproduct nootropics (pre FDA appoved as these are natural products) as well as find a number of harmful natural materials that humans can learn to avoid. It is possible this might be less than $10,000 overseas

That's just to buy the mice.  They would need cages and equipment, maybe $10/mouse?  Then they would need food and water for their lifetime.  Another $10/mouse?  They would need an air conditioned building for ~4 years, maybe $60,000, and a person to care for them, maybe $100,000?

That raises the price to $2.7 million...

[treonsverdery]

actually that .59c per 24 hours is the Washington State University fee to provide, feed, as well as provide all supervision to a mouse
note the link http://www.vetmed.ws...iemFY11-12.xlsx


now the grads or undergrads blenderizing things, then deciding if they want to provide fresh or bulk frozen material to the animal facility is another thing

I think searching mass fractionated tissue to find new bioactive chemicals that are definitionally automatically FDA approval category could be of value

[niner]

treonsverdery, on 17 July 2012 - 08:25 PM, said:

actually that .59c per 24 hours is the Washington State University fee to provide, feed, as well as provide all supervision to a mouse

Oh, sorry,  I totally misunderstood that.  I had mouse lifespan experiments on my mind.  Are you thinking about nootropic compounds?  (title says longevity)  It seems like it would be hard to find a longevity drug only following the animal for 2 months.