12 replies to this topic

[dear mrclock]

http://en.wikipedia.org/wiki/IGF-1


was going through this and i believe this can help with cognition. anyone ever thought about trying it and reporting on effects ? im sure the actual protein is with prescription, but i wonder what drugs/supplements can influence it ?

[kevinseven11]

Deer Antler velvet is suppose to contain this but absorption is in question.

[dear mrclock]

i read deer antler supposely had some steroids in it that boosted performace and sex drive. but i never cared enough to research it further or to try it.
supposely, IGF-1 is delivered intranasal in studies demonstrating effects on the brain. kind of makes it useless by oral absorption i guess. until further studies are found of course. but as a protein, i doubt it will work :(

[Werper]

Here is the company that produces the real deal (and no it is not available ) It's a drug called Iplex that has a binding protein. When they were producing it, it cost 130 k a year to those that qualifiy to take it(als patients, currently being studied in premature babies with retinopathy.) Shareholders are expecting news shortly on this drug as to future plans with it (monetizing it in some form- partner, selling it..etc)

http://www.insmed.com/iplex.php

[88LS]

I know Cerebrolysin increases IGF1, IGF2 and GDNF quite dramatically.

The other one to look into is Colostrum, its known to raise levels of IGF1 and IGF2

http://www.ncbi.nlm....les/PMC1148968/

[dear mrclock]

thats a really old study. i wonder why they didnt have any new ones for 2 decades.

also, i cant find carebrolysin being sold anywhere in usa, any idea ?

[dear mrclock]

hmm i just did search and found other carebrolysin threads and it seems that you have to inject it. thats not something i want then. i wonder if they produce orally available choice ??

[Jbeatty]

I have done it for weight lifting purposes and I don't remember it enhancing anything cognitively and the deer velvet does not work from what I have read. It also can increase a risk for cancer so I wouldn't be willing to try it again. Starting cerebrolisyn tomorrow though!

[Jbeatty]

And the only way I know of taking it is IM injection just like cerebro

[88LS]

dear mrclock, lol sorry I didn't realize the study was that ancient, here's more recent info:

Colostrum Wikipedia - Low IGF-1 levels may be associated with dementia in the very elderly, although causation has not been established.^[35] People with eating disorders also have low levels of IGF-1 due to malnutrition,^[36] as do obese individuals.^[37]Supplementation with colostrum, which is rich in IGF-1, can be a useful part of a weight reduction program.^{[citation needed]} Although IGF-1 is not absorbed intact by the body, it does stimulate the production of IGF-1 when taken as a supplement.^[38]

http://www.ncbi.nlm....pubmed/12133885

Cerebrolysin is only for IV or IM injection yes and you'll have to import it, got mine from http://superhumangear.com/store_wp/

[albedo]

I am trying doing to reverse and lower my level of IGF-1. At 57 I have IGF-1 at 240 ng/mL (ref: 81-225). I am trying lowering protein intake, increasing exercise and lowering calories. Is this the right order? Should I focus on something else?

[dear mrclock]

i thought its good to have increased IGF1 at older age. check out tablet of how women have it higher than men as they age and might be one of the many reasons they live longer and healthier than men.

[albedo]

I should have mentioned I am a 57 yo men and was led to this line of thinking for prostate concerns and supplementation (posted all HERE and would appreciate comments there if interested). I keep we need to be cautious with hormones and supplementation supposed changing their balances. IGF-1 looks to increase risk of PCa and you need to be cautious if you have other risk factors (as I do). AFAIK and related to IGF-1/PCa we might (i) need to look rather at IGF-II (but need to research on this, see http://connection.eb...-pca-than-igf-i and thank you zorba990 for the pointer) and (ii) while all I found goes along the line of an association of high levels of IGF-1 and PCa, we might have low IGF-1 levels associated to more aggressive disease: "...On the other hand, decreased IGF action, subsequent to the down-regulation of IGF-1 receptor expression, is associated with advanced, metastatic disease..." http://www.ncbi.nlm....pubmed/15562830