Modafinil is the closest thing to a wonder drug. It's stimulating and neuroprotective. Adderall is the best and strongest but comes with the sides of any amphetamine. You got too many cholinergics, all you need is Galantamine - it is the most powerful one of them all and has effects on nicotonic receptors. Memantine is not a nootropic, it in fact impairs cognition, and is best used as an anti-tolerance agent. If you have modafinil or adderall, you don't really need the hydregine or selegine.
Of the racetams, I think aniracetam is the best, but it's half life is only 2 hours. Pramiracetam is strong, but I think overrated, and too much can raise NO levels which kill neurons. Oxiracetam is very good too, the only racetam to give me noticable cognitive effects when I was measuring things. Bacopa works but can be sedating.
Forskolin is very potent but cAMP can works both ways... improving and impairing cognitive function - but you'll feel it when you take it. Idebenone is also good but the effects fade after a day or two of continous use.
Modafinil is stimulating and helps get things done, but like Adderall is not a Nootropic at all. In fact some classify Adderall and Modafinil as anti-nootropics. Adderall is known to suppress creativity and in the long-term is only negative to cognition. Modafiinl does not have these side effects so it's nice. Nowhere near wonder drug as you describe it though. It just gives you the power to avoid sleeping with almost no side effects.
When you say I have too many cholinergics you need to observe the way Piracetams and Cholinergics work. A lot of nootropics users think of Choline as being some sort of energy or whatever that you need a certain amout for Racetams to work. However it's much more. For example CDP-Choline is proven to upregulate dopamine receptors and also to have a synergistic effect with Alpha-GPC because these two work at the both ends of the cholinergic spectrum. Centrophenoxine is a cellular detoxifier as it's known to be able to clear out fat deposits in brain which diminish neuron's ability to communicate. I'll admit here that I have no real idea what Hydergine does yes I only read that it might potentiate the effects of all Piracetams. So you have Pramiracetam which potentiates the effects of other racetams, Aniracetam which is 30x stronger that Piracetam and Hydergine which again potentiates them and Noopept which is already 1000x stronger than piracetam and is yet to be potentiated by Prami and Hyder. Think again whether I'll need that choline or not
Galantamine comes in only every now and then to keep AcH receptors sensitive.
I read that Memantine is succesfully used in patients with severe Dementia, so I thought to myself it might actually be a potent nootropic. Why you think it's not remains a mystery to me. Truth is I am not familiar with memantine so I won't make any fast judgements.
You say pramiracetam can raise NO levels ? That's interesting - I do have cerebrolysine and Lion's Mane which will most definitely protect neurons from such damage but I might want to research on how to diminish NO levels when on Prami.
Again - different racetams are different, not just in potency. Pramiracetam is mostly valuable because it potentiates other racetams. Aniracetam is great. Oxiracetam works only for 2 hours of reading it's not good for long sessions because it depletes your neurotransmitters. That's why I'll stick with Prami + Ani + Noopept for now and try Oxi only if I need to get even closer to Photographic memory which is doubtful.
I've been into bodybuilding for some time and I've tried Forskolin to raise my cAMP levels, because cAMP is the fastest way to induce ketosis on a no-carb diet. However Forskolin did not work at all for me. No noticeable increase in cAMP levels. I think Forskolin is just myth. If you want a significatn cAMP increase you need clenbuterol.
Cerebrolysin with methylene blue and amphetamine must push the brain to extreme limits, id even say it would be healthier then just amp as the other 2 are neuroprotective.
If i had the money id try it, its clear that we all are far from getting the max out of brain like that guy that exactly remembers all details of everyday of he's past life.
I wouldn't try amphetamine. It's old school, it's neurodamaging and it's not really a nootropic. Sides are too harsh, not only on the brain but on liver as well.
MB and cerebrolysin would dramatically upgrade the capacity your "engine" can run allowing amp to max it out far more, it sounds deadly but amp can only max things out as much the engine allows anyway.
For anyone that sponsers cerebrolysin ill try it:)
nefiracetam prob is a good add on too as it dramatically potentiates the glutaminergic system wich plays a main role in cognition also is a cAMP doner so potentiates LTP.
Im curious how much you can max the brain out, i dont think you can damage the brain by maxing it out to much except with things like amp but its known that the brain can handle it on a temporar basis (altough the sciencetis that was addicted to its he's whole life and produced an amazing output differs).
Amp looks like what N2O is for sports cars lol. I'm pretty curious how MB actually works and how should it be used. I'm definitely up for it. Still Amp is a no-no for me. I haven't heard of Nefiracetam yet but I'm interested now. I'll check it out.
It's very important to understand that what we are doing here is not forcing the brain to work above healthy limits. I think our mission here is to fix the damages on our brains done by centuries of cognition neglection and suppression which has lead to us becoming very stupid creatures. Our brains are sports cars and we've been using only the first gear all these years.
Check these out as well: RolipramNebracetam (very important - muscarinic M1 receptor agonist)
Edited by Tatsumaru, 06 October 2012 - 03:40 PM.
