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progeria drugs to prevent aging

hutchinson-gilford progeria progeria lonafarnib pravastatin zoledronate

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#1 ClarkSims

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Posted 25 December 2012 - 05:51 PM


Does anyone have an opinion about progeria as a model for senescence in ordinary people?

http://www.ucsf.edu/...ht-normal-aging


But in one of those expansive, “I hate to ruin your morning,” moments, Collins went on to present evidence that progerin is being made by a fraction of cells in all of us as we age, albeit in much less dramatic fashion.

Telomeres, Progerin and Normal Aging

Rather than being caused by any deadly genetic mutation we are born with, these more leisurely cellular breakdowns might involve a loss or shortening of protective telomeres, Collins suggested. Collin’s lab team found that in cells growing in the lab, when they used a chemical to un-cap the chromosome ends, it altered gene splicing and led to progerin production and cellular senescence.

“It’s clear that progerin turns on as a cell is approaching senescence,” Collins said.

“It’s not ubiquitous low-level expression.” In cells that are affected, he said, “The cells make almost as much as in a patient with the disease.”

Here is an article about lonafarnib and progeria


http://news.sciencem...xed-review.html
  • Informative x 2

#2 Santi

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Posted 20 May 2015 - 01:50 AM

Anyone have any thoughts regarding using a progerin inhibitor for anti-aging until we have a more efficient way to clear out senescent cells than quercetin and dasatinib?

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Also tagged with one or more of these keywords: hutchinson-gilford progeria, progeria, lonafarnib, pravastatin, zoledronate

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