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[Lonewolfe1978]

I've been looking for semi-recent (last 15-20 years, at the outside) studies of centrophenoxine which take up human subjects, and I'm not finding much. Is anyone aware of any that are out there? I'm finding plenty on rats and monkeys and what-not, but nothing on humans except one which seemed to conclude with some strong skepticism that while it's possible that centro removes lipofuscin, there is little evidence that it does so in humans and even less understanding of the mechanism by which it might accomplish that task.

[LBGSHI]

Unfortunately, the only human studies I'm aware of are these three:

http://www.ncbi.nlm....v/pubmed/375944 - Prolongation of the mitotic life span of diploid human glia cells in a quantitative cell culture system by centrophenoxine

http://www.ncbi.nlm..../pubmed/2912915 - The formation of autofluorescent granules in cultured human RPE

http://www.ncbi.nlm..../pubmed/1945368 - The Hungarian version of the Nuremberg Geronto-psychological Inventory

...of which the first two are in-vitro (in human cell cultures, not in live humans), and the third is quite vague in its conclusion regarding centrophenoxine (let me know if you understand it explicitly, because I don't). As a note, the second study above indicates that centrophenoxine does not effect lipofuscin deposits, though admittedly it uses only a specific type of simulated lipofuscin, and only retinal pigment epithelial cells.