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Another non psychedelic 5HT2A agonist identified


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#1 medievil

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Posted 09 March 2013 - 11:44 PM

Eur J Pharmacol. 2002 May 24;444(1-2):39-45. Pteropodine and isopteropodine positively modulate the function of rat muscarinic M(1) and 5-HT(2) receptors expressed in Xenopus oocyte.
Kang TH, Matsumoto K, Tohda M, Murakami Y, Takayama H, Kitajima M, Aimi N, Watanabe H.
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Japan.
Pteropodine and isopteropodine are heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC, a Peruvian[color=#1B8EDE !important][background=transparent !important]medicinal plant[/background][/color][color=#444444] known as cat's claw. In this study, the effects of these alkaloids on the function of Ca(2+)-activated Cl(-) currents evoked by stimulation of G protein-coupled muscarinic M(1) acetylcholine and 5-HT(2) receptors were studied in Xenopus oocytes in which rat cortex total RNA was translated. Pteropodine and isopteropodine (1-30 microM) failed to induce membrane current by themselves. However, these alkaloids markedly enhanced the current responses evoked by both acetylcholine and 5-hydroxyhyptamine (5-HT) in a concentration-dependent and reversible manner with the maximal effects at 30 microM. Pteropodine and isopteropodine produced 2.7- and 3.3-fold increases in the acetylcholine response with EC(50) values of 9.52 and 9.92 microM, respectively, and 2.4- and 2.5-fold increases in the 5-HT response with EC(50) values of 13.5 and 14.5 microM, respectively. In contrast, in oocytes injected with total RNA from the rat cerebellum or spinal cord, neither alkaloid had an effect on the metabotropic current responses mediated by glutamate receptor(1 and 5) (mGlu(1/5)) receptors or ionotropic responses mediated by N-methyl-D-aspartate, kainic acid or glycine. Pteropodine and isopteropodine (10 microM) significantly reduced the EC(50) values of acetylcholine and 5-HT that elicited current responses, but had no effect on the maximal current responses elicited by acetylcholine and 5-HT. On the other hand, mitraphylline, a stereoisomer of pteropodine, failed to modulate acetylcholine- and 5-HT-induced responses. These results suggest that pteropodine and isopteropodine act as positive modulators of muscarinic M(1) and 5-HT(2) receptors.[/color]

After ginseng cats claw... more to come but hard to find things.

#2 Azzidic

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Posted 09 March 2013 - 11:50 PM

Might be good for treating tension headaches.

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#3 medievil

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Posted 11 March 2013 - 11:46 AM

Found more 5HT2A agonistic herbs, but herbs is a bad word as mescaline cactus and stuff would also fall under that, herb more refers to plants but ones that are addictive, strong, psychoactive are absolutely excluded and more seen as medications paradoxally, like if someone asks a herb for anxiety or for being social cocaine or opium isnt what they want to hear, they want salad extract thats weak works but mildly and has alot of health benefits.

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#4 Galaxyshock

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Posted 12 March 2013 - 05:52 PM

Cat's claw is interesting stuff. NMDA-antagonist, MAOB-inhibitor, 5HT2A agonist...

Rhynchophylline has DMT structure to it:

Posted Image


Some report mild visuals etc. from it. For me in high doses it was quite dissociative and made me think about universe, death and that sort of things..
But yeah it's not classified as psychedelic.

Also tagged with one or more of these keywords: 5ht2a

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