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[Xenix]

How accurate is it (really) when trying to simulate AD in rat models? It currently seems to be the 'gold' standard of measurement in labs, but Scopolamine is just an anticholinergic (blocks transmission of acetylcholine); how exactly does treating rats with it simulate the neural tissue damage, hippocampal shrinking, and all the other horrible nastiness that occurs in the symptoms of people suffering from AD?

[Bonee]

As far as I know there is genetic models for AD in rats with increased amyloid accumulation.
like this
http://www.ncbi.nlm....pubmed/23575824