3 replies to this topic

[Planteater]

I have some Sel Hcl liquid and want to try and make a patch out of it for transdermal delivery. Is there a way to do this?

alternately I try rubbing it on my gums. How effective is this in bypassing the oral route and is it absorbed well that way?

Another thing I was thinking was to put it up my nose: would this work well?

That's three questions and I am wondering if anyone with a science background could advise on Any of these questions.I know from the spec sheets on the prescription selegiline patch that it uses DMSO, so I was thinking of somehow making my own patch.

My purposes are low dose cognitive enhancement and definitely not mao a inhibition. I have used it before so know how I respond.

[panhedonic]

Why don't you just take it sublingual?
BTW, if you are worried about MAO-a inhibition, how are you going to control your dose? as far as I know the literature only gives you guidelines for oral administration (up to 10mg/day safe for only MAO-b inhibition)

Incidentally, I take 5mg/day sublingual and monitor my BP without any changes so far, consuming cheese and wine liberally. ]

[Planteater]

So I guess since it is liquid deprenyl I can just put in under my tongue?

My main concern is avoiding meth metabolites.

The part about MAO-A was just FYI-- I take 1mg on occasional days so I am not even close to maoai. I do not like my mao-a messed with at all, it's quite counterproductive for me. just looking for MAo-B inhibition and by-passing the meth, and I am experienced with dep and definitely notice the small dose: even 1 mg daily would be too much for me.

So: does sublingual liquid get absorbed well in the mouth? Will that avoid meth? I assume its not perfect since some goes to the stomach inevitably, but does anyone know how much meth metabolites can be avoided through sublingual route?

[golden1]

it's such a small amount of l-methamphetamine I really doubt it matters and afaik there is no way to really avoid it from metabolizing to l-amphetamine and l-methamphetamine.
http://en.wikipedia....methamphetamine