6 replies to this topic

[Ukko]

Long time lurker. Been into life extension for like 20 years. Used to be active on sci.med.life-extension ages ago. Low carbing off and on since 1995 too. Age about 40, male. Interested in general health, life extension and cognitive enhancement. Here's my current stack. Improvement ideas welcome. 

Vitamins and Basics:

1) LEF two per day; nice stuff, check the ingredients. Only gripe is D2 form of VitD and lack of broader tocopherols. But has really cool forms of zinc and chromium etc.
2) 5000-10000 i.u. VItD3, depending on season;
3) 400mg mixed tocopherols, with some tocotrienols;[I know, compete for absorption};
4) Jarrow MK-7 K2;
5) roughly 2000mg of extra vit C, varies;
5) sometimes extra B12 (methyl form), folate (methyl form), p-5-p and niacin. Looking into Thorne methyl guard right now. Tend to take 1000mg of TMG daily just to be safe;
6) Zinc 30-60mg as additional OptiZinc zinc methionine. Copper deficiency for males in reproductive age is a scam;
7) Magnesium: about 250-500 mg as magnesium taurate, another 200-400mg often as glycinate

Amino acids and the like:
1} varying amounts of L-Arginine for sports
2) varying amounts of creatine for sports
3) try to remember to take 2000mg of Taurine nightly
4} often 500-1000mg of basic tryoptophan nightly
5) sometimes L-theanine. love it. for many things, like meditation support.
6] 10mg of glutamine with whey for sports and brain glucose synthesis when on low carb

Mitochondrial boosters etc.
1) at least 300mg of NA-RA-ALA daily. Up to 3000mg of racemic ALA if needing to lose weight
2) Optimized Carnitine from LEF with like 800 of ALCAR and some Carnitine as arginate and propiylate too
3) Jarrow's MB Cell Reset. Has cool stuff from pterostilbene to shilajit to resveratrol
4) around 3 pills of bioperine boosted 95% curcumin extract
5) 100mg of ubiquinol
6) 20mg of PQQ

Nootropics and hormones {when needed}
1) sulbutiamine, pyritinol, picamilon...bought these...using them off and on. Not really noticing anything. But hey...downing them before they expire...slowly.
2) 250mg of CDP choline...seems overpriced, taking choline and inositol too
3) 300-900mg of phosphatidylserine. This stuff works great. Need a high dose though.
4) pregnenolone and DHEA ... off and on... want to avoid impacting bodily production

And of course a ton of fish oil in capsule form daily.

Stuff I have tried but given up: 1} SAM-E...too pricey 2) green coffee, pure EGCG, raspberry ketones etc. for fat loss...more like GI health loss 3) LEF mitochondrial energy optimizer...way too pricey...will whack your nerve function giving numbness as it has way too much B6 and 4) LEF Cognitex...too pricey. Also gave up on the CILTEP stack. Forskolin lowers adiponectin = become fat, uncool. All of the CILTEP stack and tyrosine boosters make me too edgy in a wired uncool way. Do want to try the uridine based stack though. Not much of experience with most nootropics...tried some, but not convinced.

[DorianGrey]

I think you could optimize your Tocotrienol regimen, you know that already. Looks like wasting money. I am not sure about the Taurine, looks high to me. Agree with copper and zinc, although you go quite high with zinc. 15mg should already be sufficient.
For myself I decided against ubiquinol. I am not convinced mitochondrial boosters like ubiquinol are needed when young (<60years), but I am not an athlete, so your situation may be different.

How exactly do you do the low carbing? I intend using Cycloastragenol (for Telomer length restoration), maybe 4 months a year. That would go well with low carbing, I think four months I can do.

[DorianGrey]

How exactly do you do the low carbing? I intend using Cycloastragenol (for Telomer length restoration), maybe 4 months a year. That would go well with low carbing, I think four months I can do.

Correction (doesn't let me edit): I was thinking low calory intake, not just low carbohydrate (Atkins?).

[Ukko]

How exactly do you do the low carbing? I intend using Cycloastragenol (for Telomer length restoration), maybe 4 months a year. That would go well with low carbing, I think four months I can do.

Correction (doesn't let me edit): I was thinking low calory intake, not just low carbohydrate (Atkins?).

Well, I have research the calorie restriction a lot over a few decades. The evidence generally supports the view that it is actually about carb and hence insulin restriction. Diabetes is accelerated aging. Carbs are massively,anabolic as is insulin and IGF-1. Proteins are really only building blocks. Fats are fairly inert, their main adverse effects being conveyed only indirectly through their adverse impact on insulin sensitive. Them being saturated fats. Easier and just as healthy to limit carbs. Well maybe methionine too.

[DorianGrey]

I didn't know you need to reduce methionine, probably hard to do as it's one of the essential amino acids. What's the detrimental effect? I know it's often prone to demethylation in proteins and affects protein function then, but still you need it to build those proteins in the first place.

I guess I have to do an assessment where I stand with my carb intake. I already avoid whitebread, pops, cake, beer but I do eat bread with fibre and drink fruit juice with high antioxidant levels. Is there a good book that has actually enough details to come up with a good but realistic diet plan (e.g. advice on bread: there are virtually hundred's of breads (Sour dough? Pumpernickel? 7 grain?), so a book that assumes you had been just eating white toast wouldn't be that great. What about the books by Lisa and Roy Walford? They are quite cheap, but are they any good? Both have 4 out 5 stars on Amazon.com. Some of the other books cost a fortune.

Edited by DorianGrey, 16 May 2013 - 12:18 AM.

[Ukko]

I didn't know you need to reduce methionine, probably hard to do as it's one of the essential amino acids. What's the detrimental effect? I know it's often prone to demethylation in proteins and affects protein function then, but still you need it to build those proteins in the first place.

I guess I have to do an assessment where I stand with my carb intake. I already avoid whitebread, pops, cake, beer but I do eat bread with fibre and drink fruit juice with high antioxidant levels. Is there a good book that has actually enough details to come up with a good but realistic diet plan (e.g. advice on bread: there are virtually hundred's of breads (Sour dough? Pumpernickel? 7 grain?), so a book that assumes you had been just eating white toast wouldn't be that great. What about the books by Lisa and Roy Walford? They are quite cheap, but are they any good? Both have 4 out 5 stars on Amazon.com. Some of the other books cost a fortune.

Check this: http://www.fightagin...restriction.php

Carbs kill. Seriously. Read up on what happens to Masai when they move from the rural areas to cities and shift from a 100% cow based (meat, organs, milk and blood) to more of a modern carb based diet. New diseases appear. Diabetes, heart disease and the like.

[DorianGrey]

Change my diet a bit, more salad, less in the evening. Down 10lbs in a few weeks (82kg to 76kg), and have only just started reading, got a book written by the Walford offspring, our public eLibrary has a few CR books. There's a bit of BS and lots of common sense knowledge reiterated, but also a few interesting facts, so in the end it's worth reading.

Just wonder why the father who pioneered CR only (?) made it to 80 years? Okay, that's anecdotal evidence but still...

Edited by DorianGrey, 31 May 2013 - 04:31 PM.