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Cerebrolysin Nasal Spray

cerebrolysin

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#121 Psionic

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Posted 03 September 2013 - 09:38 PM

Can someone tell me if you would need a needle to get the stuff out of the Vials? Or is it pourable? I love to try this stuff but just can't have needles about the place due to being an x drug user.

Was planing on using it in a nasal pump spray.


You can pour the cerebrolysin off the vial with some effort using the soaking hose of nasal spray which I done :) I also thought that it will pour when breaking off, but its not the case, cerebro is somewhat dense in order to get it from thin orifice. Also some basic pipette can be used to do the work.



Good info thanks.


Now I am using the storing syringe with some 4mm aquarium tube to get cerebro off the vial. It works perfectly! :-)
Also today I tried chitosan for the first time (unfortunatelly with yesterdays TULIP and todays 300mg Q10 with PQQ). I probably used also too much chitosan and the Cerebrolysin applied was only 1ml as usual.. the results of this combination was very profound and after the whole day I can still feel the stimulation. Next time I will try only Cerebrolysin & chitosan without any other additives to see how big their impact really was.

#122 Krabby

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Posted 04 September 2013 - 05:49 PM

I'm pretty disappointed, I have not really got any effect from Cerebrolysin at all and it has been 5 days. I'm thinking of maybe upping the dose but I'm not sure that it is good for my nasal wall. I hope that I am applying it correctly.

On another note I have been off it for 2 days and I am suddenly feeling really spaced out and stupid.


It took me 11 days to start responding. Keep it up its worth it imo ;)


Yeah, I just started again today.
I feel very confused and disorientated for a few hours after I take it which is concerning.
I really hope that it is not doing any damage to my brain... Does anyone know if that is possible?
I hope I will start to see some positive effects because at the moment all I am getting is really bad ones.

Does anyone know if it would be a good idea to take it before bed?

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#123 Sholrak

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Posted 05 September 2013 - 12:32 AM

I'm pretty disappointed, I have not really got any effect from Cerebrolysin at all and it has been 5 days. I'm thinking of maybe upping the dose but I'm not sure that it is good for my nasal wall. I hope that I am applying it correctly.

On another note I have been off it for 2 days and I am suddenly feeling really spaced out and stupid.


It took me 11 days to start responding. Keep it up its worth it imo ;)


Yeah, I just started again today.
I feel very confused and disorientated for a few hours after I take it which is concerning.
I really hope that it is not doing any damage to my brain... Does anyone know if that is possible?
I hope I will start to see some positive effects because at the moment all I am getting is really bad ones.

Does anyone know if it would be a good idea to take it before bed?


No, it's totally benign. There is no way this can hurt you more than piracetam or Modafinil for example.

The disorientiation you say, it' like a light headed feeling? It may be the rush Cerebrolysin gives you after injecting. It becomes milder in time, and is corresponding to a sudden NGF raising and the superclarity and freshness feeling it provides. Don't worry fot that, you'll eventually see it as a good thing.



Looking at Cerebro's course in a retrospective way gives me more data about it's potency. I think of those days now, and I'm convinced it was too superb to be real. What makes it so good is being that effective and the fact you even hardly you can notice that those days.

This makes auto critical thinking obligatory. Not only because if you don't give all you have while on it you are wasting money, but also because each dose you get is smally less effective than tthe next (at a very slow rate of course). It's like a chance to change everything you don't like in your life that slowly goes vanquishing (the "lifetime" tolerance property of this drug, probably) as you go using this.

Right now, I'm a bit afraid, its effectiveness dissipates someday. I can attest I don't suffer any withdrawal or addiction to it, I just ask, "what if I can never get out of it?". It's certainly a powerful tool that can be used with caution and still will have such an impact of your life, you can't go back with what you have done and the barrier you have crossed.

I will try to start soon a full month cycle. Right now I feel I have advanced a lot bbut at the same time I realize how much there's still left.

Definitely, variety of scenarios and situations experienced witht his is clearly recommended. Just ask yourself, "what do you wanna learn today?" and make it true.
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#124 Krabby

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Posted 05 September 2013 - 09:57 PM

I'm pretty disappointed, I have not really got any effect from Cerebrolysin at all and it has been 5 days. I'm thinking of maybe upping the dose but I'm not sure that it is good for my nasal wall. I hope that I am applying it correctly.

On another note I have been off it for 2 days and I am suddenly feeling really spaced out and stupid.


It took me 11 days to start responding. Keep it up its worth it imo ;)


Yeah, I just started again today.
I feel very confused and disorientated for a few hours after I take it which is concerning.
I really hope that it is not doing any damage to my brain... Does anyone know if that is possible?
I hope I will start to see some positive effects because at the moment all I am getting is really bad ones.

Does anyone know if it would be a good idea to take it before bed?


No, it's totally benign. There is no way this can hurt you more than piracetam or Modafinil for example.

The disorientiation you say, it' like a light headed feeling? It may be the rush Cerebrolysin gives you after injecting. It becomes milder in time, and is corresponding to a sudden NGF raising and the superclarity and freshness feeling it provides. Don't worry fot that, you'll eventually see it as a good thing.



Looking at Cerebro's course in a retrospective way gives me more data about it's potency. I think of those days now, and I'm convinced it was too superb to be real. What makes it so good is being that effective and the fact you even hardly you can notice that those days.

This makes auto critical thinking obligatory. Not only because if you don't give all you have while on it you are wasting money, but also because each dose you get is smally less effective than tthe next (at a very slow rate of course). It's like a chance to change everything you don't like in your life that slowly goes vanquishing (the "lifetime" tolerance property of this drug, probably) as you go using this.

Right now, I'm a bit afraid, its effectiveness dissipates someday. I can attest I don't suffer any withdrawal or addiction to it, I just ask, "what if I can never get out of it?". It's certainly a powerful tool that can be used with caution and still will have such an impact of your life, you can't go back with what you have done and the barrier you have crossed.

I will try to start soon a full month cycle. Right now I feel I have advanced a lot bbut at the same time I realize how much there's still left.

Definitely, variety of scenarios and situations experienced witht his is clearly recommended. Just ask yourself, "what do you wanna learn today?" and make it true.


That was a beautiful answer. :)

I have noticed that after taking it at 1:00pm some rather pleasant effects will occur at around 11pm and will last through the next morning until I dose again.

Unfortunately I dosed this morning at the same time with 1ml of cerebro and the same awful effects have lasted throughout the day. It is very hard to explain but I just constantly feel confused and often I am left pondering over simple tasks such as navigating a menu as it will take me a few seconds to figure out how to use it. It is like my brain has gone blank in that period of time. I have been playing a few video games and I have realised that I have to pause for a second to remember the controls and I often press the wrong button. My head kind of feels heavy, particularly at the front. It is like someone is compressing it or it is being scrunched up and I need to relax for it to go back to normal (which I can't do).

I am thinking tomorrow I will try a lower dose to see if that is the problem. But I don’t see how I could be overdosing as it should translate to 5-7ml.

Does anyone else have these symptoms when starting out on cerebro?
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#125 spookytooth

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Posted 07 September 2013 - 02:17 PM

Has anybody ever thought of using Cerebrolysin in an eye drop solution? NGF can be administered this way.

#126 Passion

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Posted 07 September 2013 - 11:03 PM

Anyone thinking of treading this path and administering Cerebrolysin intranasally should REALLY STOP AND THINK ABOUT IT. Few people on the boards have done this and we don't know the details of the preparation used in the lab studies. ONE MEMBER HAS HAD SEVERELY ADVERSE EFFECTS using this route of administration. His original entry was posted in the Cerebrolysin thread but was deleted due to inappropriately negative response from the community.

I thought I would post here about my experience because it has more to do with the cerebrolysin itself. I would like to know if anyone else had experienced this and if anyone has any advice in order to help my situation.

After reading about nasal administration of cerebrolysin I thought I would give it a shot as I do not trust myself with needles and I felt that it would get me in a good mind-set for university which is approaching. I dosed for about 5 days at 1pm with 1ml (0.5ml in each nostril which translates to about 5-7ml IM according to the research papers) without noticing any effect apart from a slight headache and pressure on the front of my brain. After this I took a 2 day break like some people have suggested as I was out of town. On these days I noticed that I would lose concentration slightly when focusing on something and I found trying to operate a new piece of technology harder than it would usually be for me.

After taking the cerebrolysin the next day after this break I felt a very distinct pressure at the top of my head very quickly after dosing. It sort of felt like a heavy headache but without the pain, It had the symptoms of what I felt the day before but amplified. Throughout the day I felt constantly confused, it would take me a long time to process any information at all and my memory was very poor when trying to recall information. I just felt like going to bed the entire day. At 11pm however the bad symptoms seemed to dissolve away and I felt quite a pleasant feeling of a clear mind and general happiness. This is what I thought cerebrolysin was supposed to feel like. This feeling lasted throughout the night and into the morning, even after sleeping.

At 1pm, still experiencing the ‘good’ effects, I thought I would dose again as I thought the bad symptoms were a factor of my body getting used to it. After applying 1ml into my nasal cavity I quickly got hit by the worst experience yet, it was like the day before but much worse. It was so bad that I was unable to do any work at all throughout the day. My brain just felt like it was being squashed or tangled. It’s kind of the feeling you get when you’re stressed and you relax your brain in order to get clear head (except that does not work). I waited the whole day as I thought the same thing would happen around 11pm. It did not.

It has been 3 days since I have taken any cerebrolysin and the horrible effects are still there. I am even finding writing this passage very difficult, sorry for the bad sentence structure. I have tried to play some video games and I have found that I am taking a very long time to learn the controls and that it will take me a few seconds in order to figure out which button to press. Simple menus on the TV, for example, have suddenly become very challenging as I am unable to focus on what I am doing with the looming sense of confusion and heavy head. I just feel like going to bed right now even though it does not seem to help in any way. It just feels like I have a headache constantly and I am unable to do any work at all. I thought this might be due to the fact I took an ‘overdose’ and a smaller does would help the situation but I am afraid to take any more. I'm starting to think the bad effects I am getting are the good effects everyone else is getting.

I would like to know if anyone else has ever had these sorts of effects, from the things I have read nobody has really had any bad experiences which is getting me worried.
University is approaching soon and I really hope that this does not last until then.
Thanks!


He has posted a separate thread on the matter here:
http://www.longecity...effects-advice/

Please be advised. I would highly recommend against experimenting with eye droppers as well.

Note: I am not a doctor and the information above is for informational purposes only.
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#127 Nattzor

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Posted 07 September 2013 - 11:19 PM

I know atleast one dude who got an extremely severe panic attack from doing it IM, should people stop it because of that? There will always be outliers who get extreme results from any drug. The MoA will be the same for cerebrolysin IM/IV and intra nasally, so it would most likely happen to him anyway.
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#128 nuc

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Posted 16 September 2013 - 11:26 AM

Ok so, can this stuff be taken sublingually or not? Is it possible to mix it with some powder and let it get absorbed, then can be snorted?

#129 Plasticperson

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Posted 25 October 2013 - 09:58 PM

Warning: I've felt very weird ever since taking cerebrolysin nasally. My symptoms include: deppression, adominal pain on right side, uncontrollable shaking after smoking marihuana, tingling in feet, feeling cold. I think the shaking is starting to happen sober now too. I'm very concerned about possible prion exposure. Apparently prions piggy back off of a proteins found in the intestinse. If anyone has any information of nasal cerebrolysin/ prion exposure please post or pm me
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#130 Mr Matsubayashi

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Posted 26 October 2013 - 12:37 AM

Warning: I've felt very weird ever since taking cerebrolysin nasally. My symptoms include: deppression, adominal pain on right side, uncontrollable shaking after smoking marihuana, tingling in feet, feeling cold. I think the shaking is starting to happen sober now too. I'm very concerned about possible prion exposure. Apparently prions piggy back off of a proteins found in the intestinse. If anyone has any information of nasal cerebrolysin/ prion exposure please post or pm me


From what I've read on prions...

The effects depend on your genes and the prion type causing damage. Effects range from:
  • No effect
  • Alzheimers in late age
  • Dementia in about 1 year (worst case)
In the main cerebrolysin thread the risk of prions was discussed at length. Summary points are:
  • The production process of Cere should prevent whole proteins making their way into the product
  • There was one case of possible swine based prion transmission to humans in a slaughter house, other than this "mad pigs disease" is unheard of
  • Prions are are not removed by cooking, sterilization, ect. Main pathway of transmission to humans is the consumption of affected meat products
I think the good/bad effects of Cere are most likely connected to the immediate response of the human body to the amino acid cocktail and the placebo effect generated by first time injectors. The manufacturer doesn't exactly know what is actually in Cere so there might be some interesting compounds in there. The manufacturing process is very imprecise. If you cease administration most likely you will return to your old self.

If symptoms persist and you believe it might be prion damage, get a MRI to see if your brain shows signs of prion damage, imagine swiss cheese. Don't forget to update this board after!!!

I think you're fine. Don't sweat it.
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#131 vlk

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Posted 26 October 2013 - 04:20 PM

Warning: I've felt very weird ever since taking cerebrolysin nasally. My symptoms include: deppression, adominal pain on right side, uncontrollable shaking after smoking marihuana, tingling in feet, feeling cold. I think the shaking is starting to happen sober now too. I'm very concerned about possible prion exposure. Apparently prions piggy back off of a proteins found in the intestinse. If anyone has any information of nasal cerebrolysin/ prion exposure please post or pm me


As Mr Matsubayashi said, the method of cerebrolysin production makes prion exposure extremely unlikely:
One of the most effective methods of inactivating prions is by exposure to a mild sodium hydroxide (NaOH) solution -- cerebrolysin is a mixture of peptides and amino acids in a sodium hydroxide solution!

#132 Plasticperson

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Posted 10 November 2013 - 04:06 AM

I figured out why I've been feeling so bad lately. I was just diagnosed with Epstein-Barr virus. I seriously think the cerebrolysin activated the Epstein-Barr. I started getting slight symptoms a week after intranasal cerebrolysin. And full blown symptoms about 2-3 weeks later. When I took cerebrolysin IM i had slight flu effects. I'd like to point out that Epstein-Barr is a herpes virus. Herpes virus are viruses that reside in the mucous membranes. Intranasal administration is basically through the mucous membranes. Any knowledge on cerebrolysin, herpes virus, and the immune system would be greatly appreciated.

#133 Mr Matsubayashi

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Posted 10 November 2013 - 01:14 PM

I figured out why I've been feeling so bad lately. I was just diagnosed with Epstein-Barr virus. Any knowledge on cerebrolysin, herpes virus, and the immune system would be greatly appreciated.


This is terrible news. If I were in your situation I would try to identify a specialist in the field and get their involvement. Tell them everything you have taken, Cere included.

#134 gatersaw

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Posted 18 November 2013 - 12:49 AM

From what I've read; cerebrolysin or any animal derived tissue (xeno tissue) depletes glutathione. I had a few months of what physicians thought were panic attacks but actually were a much worse soy allergy reaction than I'd previously experienced. So my soy allergy reactions became much worse. I've also recently discovered I have a homozygous MTHFR C677T mutation which has built up toxins over the years resulting in toxicity of everything from mercury to these xeno tissues. Everything depletes my glutathione which explains why I get a noticeable energy boost from NAC. So I've gotten "activated B complex" from swansonvitamins.com and i'm healing rapidly. Soy reactions are now mostly upset stomach rather than insane panic attacks that feel like dying or fainting for hours at a time. I can see why some people take their lives and it's largely due to physician ignorance.

Taking cerebrolysin nasally presents an obvious potential side effect in that it will likely cause growth of the olfactory nerves as the active ingredient actually causes nerve growth.

I commend this forum for taking on the experimental use of cerebrolysin. I believe it is by far the best nootropic available and will continue taking it myself.

Edited by gatersaw, 18 November 2013 - 01:05 AM.


#135 jennster

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Posted 20 November 2013 - 08:53 PM

I'm thinking I'm going to pull the trigger on this pretty quick. What is a good dose people are still seeing results with IN? How many times a day? Is everyone mixing with water or some just doing it straight on? Sorry if I duplicated questions. I did read the entiee thread. This may be a case of trying and seeing what works for you personally huh?

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#136 cyberger

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Posted 21 November 2013 - 10:11 PM

I'm thinking I'm going to pull the trigger on this pretty quick. What is a good dose people are still seeing results with IN? How many times a day? Is everyone mixing with water or some just doing it straight on? Sorry if I duplicated questions. I did read the entiee thread. This may be a case of trying and seeing what works for you personally huh?

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There are some people who've experienced crippling side effects apparently from IN Cerebrolysin. Here's the side effect info thread: http://www.longecity...effects-advice/
You may want to try something else like NSI-189 which also promotes brain growth and is meant to be administered orally.

#137 tjcbs

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Posted 29 January 2014 - 10:39 PM

Are people still doing this, or has everyone been scared off?

Krabby, I hope all is well, I've been through similar, and it is not fun, at all.

#138 aarfai

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Posted 07 February 2014 - 05:33 AM

Just curious, anyone still doing intranasal Cerebrolysin? If so, what are your experiences so far?

#139 onz

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Posted 25 May 2014 - 11:45 AM

I ordered some cerebrolysin from reading this thread, but right before seeing Krabby's reports of longterm damage.

 

Now I feel very confused, I'm way too scared of needles, but unsure of the risk involved with IN. Theoretically it should be safer, but with Krabby's response it might not be worth the risk. But why would this occur? It's hard to tell because he hasn't tried injections before. Is it the olfactory aspect? Or the various other compounds within the injection formula of cerebrolysin? Or simply a bad batch?

 

It's so disappointing because from what I've read cerebrolysin sounded exactly like what I've been looking for, repairing damage without having to commit to everyday usage. Crossing that line into injections will be very difficult, just the thought of it makes me feel sick - I do have a friend who's a doctor in a hospital, I'll speak to him he might be able to help.


Edited by onz, 25 May 2014 - 11:45 AM.


#140 Nattzor

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Posted 25 May 2014 - 01:21 PM

I really don't know how intranasal would cause damage when injection does not. I think it's some form of nocebo or that he would have reacted like that with injections anyway.



#141 matter_of_time

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Posted 25 May 2014 - 07:59 PM

I think that the people who are afraid of injecting are trying the intranasal route.
the same people are more likely to experience some kind of anxiety or panic attack from taking cerebrolysin or any other substance.



#142 tjcbs

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Posted 30 June 2014 - 02:36 AM

Well, perhaps foolishly, I've been trying this. So far I've done 4 "cycles" of 10 ml vials, taking 1ml daily. There have been no untoward effects. I guess I don't have any virii latent in my olfactory nerves. I don't know what to make of Krabby's experience. Given its rumination-heavy nature, nocebo is highly possible. Also, I read that he used hydrogen peroxide to sterilize, I wonder if perhaps he was neglecting to rinse the dispenser afterwards. The few times I forgot, I experienced the same intense pain he described, which no one else seemed to experience, badly enough that I had to discard the Cerebrolysin in the bottle. Maybe repeatedly dousing your sinuses with h202 is not such a good idea? Unfortunately, you can drop the "untoward" from the previous sentence and it would still be true. This is such a ripe candidate for the placebo effect, given its hype and exotic mode of administration, I'm surprised I got nothing at all. It's also quite tedious to administer.
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#143 tjcbs

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Posted 29 July 2014 - 08:10 PM

Also, by using a syringe to store in the fridge, removing as many air bubbles as possible, I've been able to store it for up to two weeks without any noticeable change in taste or smell, and no negative effects. I wonder how long it can stay fresh this way? Unfortunately, still nothing particularly interesting in terms of effects.  



#144 AlexCanada

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Posted 27 May 2015 - 12:04 AM

Does it take a lot of time to prepare for the injections? Do you need to find a vein or do you just inject into your muscle/fat? Is it as simple as a quick 20 second inject and that's that? Or do you have to prepare in a certain manner?   Also the 5mg injections.... can you just inject half one day and half the next? I am very sensitive to meds and would feel much more comfortable if I could take lower doses.  Is this possible? 

 

If it's not too expensive I am hoping to maybe try this but Canadian customs is difficult.  Cere does seem remarkably promising for PAWS, negative schizo symptoms, general cognition, energy and anxiety.     I'm sick of mind numbing SSRI's and other junk. 



#145 Ark

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Posted 28 May 2015 - 06:36 AM

I'd be very excited if ceretropic carried Nasal Cerebrolysin, I wonder if they're looking into this.

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#146 PalmAnita

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Posted 06 October 2015 - 02:00 PM

How different is cerebrolysin from the isolated P21 peptide? 

 

As I've tried countless drugs before, I didn't care much (enough) before trying the P21, seeing it's synthetically made and a derivate of a decade-long administered nootropic.. my reaction has indeed been positive, very positive to be concrete (when dosed high enough), but these side effects of course raise real concerns.







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