sourceStudy of acetylsalicylic Acid role in the potentiation of antiamnesic and neuroprotective properties of piracetam in rats with alloxan diabetes
[Article in Russian]
Zhylyuk V, Lievykh A, Mamchur V.
Source
SE «Dnipropetrovsk Medical Academy of Health Ministry of Ukraine», Dnipropetrovsk, Ukraine.
Abstract
It has been established that prolonged alloxan-induced hyperglycemia in rats potentiates amnesic properties of scopolamine hydrobromide. It was characterized by shortening of the latent period by 44% (p<0,01) and by 47,7% (p<0,05) after 24 hours and on the 20th day of conditioned passive avoidance test. This effect was accompanied by increase in oxidative modification of proteins and nitric oxide synthesis in the cerebral cortex. Along with this, a significant enhancement of ADP- and collagen-induced platelet aggregation was observed. These processes may play the leading role in the development of cognitive deficit in diabetes. Meanwhile, co-administration of piracetam with acetylsalicylic acid was accompanied by an expressed antiamnetic potential - the reduction of early markers of proteins degradation (aldehydephenylhydrazones, APH) by 21,7% (p<0,05) and late markers of proteins degradation (ketonephenylhydrazones, KPH) by 23,8% (p<0,001) was noted. This combination was 15,7% (p<0,05) more active than piracetam according to the effect upon KPH. NO2-/NO3- level was also decreased by 30,3% (p<0,05) in comparison with alloxan-diabetic rats. The significant anti-platelet effect was observed: degree of collagen-induced platelet aggregation was reduced by 56,8% (p<0,01), ADP (5 μmol/l)-induced - by 31,7% (p<0,01), ADP (20 μmol/l)-induced - by 47,3% (p<0,01) as compared to the hyperglycemic rats. Such an increase in nootropic activity of piracetam may be assumed to be directly related to the ability of acetylsalicylic acid to improve microcirculation in the ischemic areas of the brain in diabetes and probably to its neuroprotective potential.
Sorry for sensationalist title - practically the authors are saying that the combination is 15% better at protecting against protein degradation in the brains of scopolamine/alloxan ridden rats, still, the finding may come in handy in case one has diabetes! Also there's the possibility that the two drugs enhance in other in a more nootropic context, I have not been able to find usage cases via google and I would advice caution the anti-platelet effect potential of the two drugs in conjunction is powerful enough to be potentially harmful (I guess, someone more knowledgeable on the subject might be able to give more educated opinion on this)