3 replies to this topic

[ta5]

I'm wondering what mechanisms contribute to the age-related increase in blood pressure?

• Increased arterial stiffness from glycation
• Vascular calcification

What else?

 

Can we say another cause is cumulative oxidative damage to blood vessels? 

Does angiotensin rise with age?

 

Thanks.

[Danail Bulgaria]

Kidney damage and kidney diseases may lead to hypertension. Many old people have a chronic kidney diseases.

 

Obesity may lead to hypertension. Obesity is common among the old people.

[dankis]

IMO it is very complex relation with many, many factors.

 

Examples:

 

Low sex hormones --> low dopamine activity-->more prolactin-->more vasopressin (prolactin directly stimulate vasopressin synthesis)

 

Worse mitochondria function--> endothelial dysfunction

 

Pathological insulin resistance --> Worse mitochondria function(...)

 

[xEva]

Another cause is portal hypertension due to liver disease. This affects the blood pressure throughout.