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Assessing the effects of c60 on human cancer proliferation in vivo

c60 ichor

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#1 caliban

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Posted 06 September 2014 - 11:44 PM


 c60re02.png  

 

"Assessing the effects of c60 on human cancer proliferation in vivo"

is led by life-extension trailblazer Kelsey Moody. It is interesting that he turns the attention of his new venture Ichor Therapeutics to the potential health effects of 'buckyballs' - a topic that has received significant attention on LongeCity ever since it was claimed in a scientific report that rats fed on olive oil infused with these structures experience dramatically increased maximal lifespans. (Review here). 
True to it mission, LongeCity hosts the leading international discussion forum on this topic. Previously, the LongeCity community has come together to fund further grassroots research on C60 in mice and these studies are on-going.

Meanwhile though, in keeping with the pioneer spirit often found on the LongeCity forums, reports have come in from people trialing C60 in olive oil on themselves. As Kelsey points out, the long-term safety of this has yet to be established, and this project is particularly interested in whether C60 in olive oil has any cancer-inducing properties. Conversely, it may be the case that the compound has a tumor–suppressing function. 

To investigate this, the team  plans to infuse a total of 25 mice with C60-olive oil of various strengths or with an inert ‘control’ solution, graft a human cancer cell line to the mice and study the results. (Full research proposal here
 
If the fundraiser succeeds it will further support the revolutionary notion of stakeholder-oriented, grass-roots science which complements, challenges and enriches academic research at those junctures that the community actually cares about. Moreover and perhaps even more importantly the fundraiser will help to built capacity and community interface at a dedicated life-extension research facility. Already, Ichor has housed an intern on a LongeCity stipend (Report here- Members only). Ultimately, we hope to create a network of such community-friendly labs around the globe, to provide aspiring young scientists
with training and networking and all members with easily accessible sources of expert advice.

LongeCity has facilitated 'crowdfunding' well before many other platforms in use today. This year, we have decided to try to tap into the potential of these external sites, but to add something to the process: This project is the first one to run on an external fundraising page that has received an official ‘stamp of endorsement’ from LongeCity.
The team has mooted the project at LongeCity, submitted for formal peer review and informal members comments and the board looked into the ability of the team to use the donated money responsibly and to deliver success (Internal link here).  In the end, the project received a high rating of 3 stars and LongeCity decided to match each dollar donation from our general funds. And, awesomely, a generous Member immediately stepped forward to match them as well!

 
This means we only need to raise $6.000 via the external crowdfunding page at indigogo. Please give generously and spread the word!

For any queries about the project to Kelsey and the team, please post below.


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#2 caliban

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Posted 12 September 2014 - 08:05 PM

After a good start with many generous donations, we were lucky to gain the attention of a know strategic philanthropist accelerating life extension research

 

And here we are... the goal has been reached in record time!

 

Kelsey has confirmed that the team is getting ready to prep the mice, while we consolidate and check the finances are all in order.

 

Given the great reception, there is no reason that it would need to stop there. If further funding was available, we could consider adding more mice to each group, to greatly increase the reliability of the results. We could also think about using some surplus funds to integrate the Ichor lab further into the LongeCity scheme of having a network of community-linked labs. For example extra funding could be used to support another intern student to gain exposure to a lab early in their education while helping with the C60 experiments.

 

If you have any suggestions please post below. At this point we are only considering options to enhance the scientific robustness of the programme described in the current fundraiser. We are not discussing new ideas or unrelated initiatives. 

 

     


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#3 Logic

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Posted 13 September 2014 - 11:43 AM

I wonder about grafting already formed cancerous cells into the mice as C60oo may be good at stopping healthy or pre-senescent/cancerous cells from turning into full blown cancers.  Whereas already cancerous cells may be protected by C60oo.
Perhaps a cancer prone strain of mouse could be considered?

Thx to Dave Gobel, Methuselah Foundation, Kelsey Moody, Ichor Therapeutics, Longecity, Donators for this study. I would love to be in that lab.

Edited by Logic, 13 September 2014 - 11:45 AM.

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#4 Ben

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Posted 21 September 2014 - 03:54 PM

Really makes me proud. Great work!


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#5 mrwhitee

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Posted 09 March 2015 - 11:05 PM

When will this experiment be completed with results?



#6 kmoody

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Posted 13 March 2015 - 12:36 PM

The methods for our study are loosely based on this paper http://www.nature.co...df/2402663a.pdf. Based on their timelines, we are anticipating the experiment to be completed around mid-April. Depending on the results, we may choose to expand the scope and size of the study before publishing our results.



#7 mrwhitee

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Posted 13 March 2015 - 05:06 PM

The methods for our study are loosely based on this paper http://www.nature.co...df/2402663a.pdf. Based on their timelines, we are anticipating the experiment to be completed around mid-April. Depending on the results, we may choose to expand the scope and size of the study before publishing our results.

 

Thanks!



#8 pone11

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Posted 18 March 2015 - 11:00 PM

The methods for our study are loosely based on this paper http://www.nature.co...df/2402663a.pdf. Based on their timelines, we are anticipating the experiment to be completed around mid-April. Depending on the results, we may choose to expand the scope and size of the study before publishing our results.

 

Any update on your study and how far it has gone?



#9 kmoody

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Posted 19 March 2015 - 12:31 PM

The study is approximately 75% completed. The trends are encouraging so far, but I would prefer not to comment on results until the study is completed. It is very easy to pick whatever data fits your meme if you shop time points in any given study. :)


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#10 Mind

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Posted 26 April 2015 - 09:32 PM

Kelsey has posted results here: http://www.longecity...ored-aml-study/

 

Encouraging enough to warrant further investigation, IMO.







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