This is interesting with re to mitochondrial antioxidans with broad functionality:
J Gerontol A Biol Sci Med Sci. 2014 Sep 4. pii: glu160. [Epub ahead of print]
Redox-Based Flagging of the Global Network of Oxidative Stress Greatly Promotes Longevity.
Canistro D1, Boccia C2, Falconi R2, Bonamassa B3, Valgimigli L4, Vivarelli F5, Soleti A5, Genova ML6, Lenaz G6, Sapone A5, Zaccanti F2, Abdel-Rahman SZ7, Paolini M5.
Despite more than 50 years of investigations into the free radical theory, the direct role of oxidative stress (OS) in aging and age-related diseases remains unproven. Little progress in identifying antioxidant drugs promoting longevity has been made, likely due to selectivity toward one or few radical species, variable efficacy in vivo, inherent pro-oxidant behavior of such drugs, or lack of synergism with metabolic redox homeostasis. Silencing the wide range of reactive free radicals has a great impact on OS-linked outcomes and age-related disorders. Here we show that an innovative, redox-active, multi-radical-scavenger catalytic drug delays the age-associated decline in physiological processes and markedly prolongs the mean lifespan of the adult freshwater annelids Aeolosoma viride by 170%. This unprecedented extension is associated with a decreased OS status. Consistently, treatment of annelids increases their natural resistance to oxygen-derived damage without affecting mitochondrial respiration or reproductive activity. Conversely, the superoxide dismutase (SOD)-mimetic EUK 134 that we selected as a positive control led to an increase in lifespan of ~50%, the same increase previously observed in nematodes. Our results show that reduction of the global network of OS has a profound impact on aging, prompting the development of a possible redox-based therapeutic intervention to counteract the progression of aging.
© The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: firstname.lastname@example.org.
Longevity; Oxidative stress
PMID: 25190068 [PubMed - as supplied by publisher]
Share on FacebookShare on TwitterShare on Google+
LinkOut - more resources
PubMed Commons homePubMed Commons