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Yeputaoteng / Ampelopsis sinica

resveratrol dihydromyricetin

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#1 hav

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Posted 18 May 2016 - 07:03 PM


Just came across an abstract about an interesting Chinese herb:

 

http://www.ncbi.nlm....pubmed/23616429

 

Yeputaoteng is the dried ground part of Ampelopsis sinica (Miq.) W.T. Wang, which is widely used in traditional Chinese medicine for preventing and treating tumors, chronic nephritis, hepatitis, rubella, traumatic bleeding, stomach heat and vomiting. A simple and reliable method using high-performance liquid chromatography with diode array detection (HPLC–DAD) was developed for the simultaneous determination of dihydromyricetin and resveratrol in Yeputaoteng.

 

Seems its main 2 active ingredients are dihydromyricetin and resveratrol. I vaguely recall dihydromyricetin being mentioned with regard to treatment of chronic alcoholism, but it looks like there's more to it...

 

Stem Cell Health

http://www.ncbi.nlm....pubmed/27171068

 

Kidney Health

http://www.ncbi.nlm....pubmed/26866356

 

Mediating Gastric Cancer via p53

http://www.ncbi.nlm....pubmed/26634523

 

Liver Health

http://www.ncbi.nlm....pubmed/25987769

 

Cardio Health

http://www.ncbi.nlm....pubmed/25226612

 

I also saw references and letters to the editor regarding an article on the similarities between dihydromyricetin and resveratrol but its all behind a paywall.  Oral bio-availability is similarly low but this abstract mentions a dramatic increase complexing it with cyclodextrin: http://onlinelibrary...0577.x/abstract

 

Howard


Edited by hav, 18 May 2016 - 07:37 PM.

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#2 Anthony_Loera

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Posted 19 May 2016 - 03:33 PM

Hi Hav,

 

I just entered "dihydromyricetin" into my email and did a search.... (I get emails constantly from material suppliers)

Yup, there are lots of suppliers of mine who appear to have this material in both 50% and 98% purity.

 

I haven't read the links much, but what is your opinion on it?

 

A



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#3 hav

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Posted 20 May 2016 - 06:28 PM

Hi, Anthony. I haven't tried it yet myself but I happened upon a small sample the other day which sparked my interest. I'm planning on mortar an pestling it with an equal amount of beta-cyclodextrin. The long history of Yeputaoteng and the more recent research on dihydromyricetin all look really promising, although the only general interest I see relates to anti-hangover. There's some even more interesting looking material related to a non-alcohol human trial of glucose & lipid metabolism behind a paywall you might want to also check out if you have access... it seems to have initiated a letter to the editor and an author reply... but I only have access to the abstract. Here are some links:

 

study:

http://www.ncbi.nlm....pubmed/26032587

 

letter to the editor

http://www.ncbi.nlm....pubmed/26382727

 

author reply:

http://www.ncbi.nlm....pubmed/26364558

 

I don't have have the ability to test or measure glucose level effects of the mix myself but hope to share it with someone who does.

 

Howard

 


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#4 Anthony_Loera

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Posted 26 May 2016 - 04:57 PM

Hi, Anthony. I haven't tried it yet myself but I happened upon a small sample the other day which sparked my interest. I'm planning on mortar an pestling it with an equal amount of beta-cyclodextrin. The long history of Yeputaoteng and the more recent research on dihydromyricetin all look really promising, although the only general interest I see relates to anti-hangover. There's some even more interesting looking material related to a non-alcohol human trial of glucose & lipid metabolism behind a paywall you might want to also check out if you have access... it seems to have initiated a letter to the editor and an author reply... but I only have access to the abstract. Here are some links:

 

study:

http://www.ncbi.nlm....pubmed/26032587

 

letter to the editor

http://www.ncbi.nlm....pubmed/26382727

 

author reply:

http://www.ncbi.nlm....pubmed/26364558

 

I don't have have the ability to test or measure glucose level effects of the mix myself but hope to share it with someone who does.

 

Howard

 

 

The end of the month steals a lot a time away from things, so I may need to circle around to this when I have a little more time, but it does look interesting.... anti- hangover? 

 

Hmm...

 

A







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