2 replies to this topic

[BobbyDick]

Nicotine - core of the stack. Nicotine in small doses administrated constantly increases ACH release of 700% but in one big dose it decrease ACH release of 40% - 50%. nAChRs agonism increase release almost all of neurotransmitters (especially dopamine and noradrenalin) and some neurotrophins (NGF, BDNF). 

I plan take 1,5 mg - 3 mg / 24 h nicotine patch because nicotine activates nAChRs very heavily even is very small doses. But in higher doses it causes mechanism called blockade depolarisation and it causes neurotoxicity.

Nicotine improve shift tasking and planing especially. Concentration, motivation and (working) memory are enhanced to.

 

Memantine 5 mg / day

It only prevents tolerance which develops very quicly.

 

Galantamine ensures constantly opened receptor. It has also big impact on memory.

 

What you think?

 

Could moderator shift this topic to "nootropics stack" subforum, please.

Edited by BobbyDick, 15 July 2016 - 08:28 PM.

[gamesguru]

the nicotine is best moderated, as you suggest, but this is difficult given its level of addictivity.  so the galantamine is preferred.

 

bacopa appears to boost global acetylcholine, and ameleorate scolopamine-induced amnesia. check out rhamnetin and tetrandrine
Flavonoids with Novel Nicotinic Activity as Potential Pharmacotherapies to Treat Ethanol-Induced Neurotoxicity
Marine alkaloids (-)-pictamine and (-)-lepadin B block neuronal nicotinic acetylcholine receptors.
 

• The active substances from the extract of ginkgo biloba act primarily through muscarinic receptors and somewhat less through adrenergic receptors. It has been proven experimentally that the application of GBE inhibits the fall of the number of muscarinic and α2 adrenergic receptors and at the same time it improves the receipt of choline in synapses and removes toxic free radicals [7,8].

 

and a bit more on ginseng (each bullet is a separate study)

• The active [non-ginsenoside] chemical constituent has yet to be identified, but the demonstrated nicotinic activity of ginseng warrants further investigation with reference to therapeutic activity in age-related conditions such as dementia.
• These results indicate that ginsenosides might regulate nicotinic acetylcholine receptors in a differential manner and this regulation might be one of the pharmacological actions of Panax ginseng.
• ... the active ingredients of Panax ginseng, inhibit subsets of nAChR channel currents, but not alpha7

[BobbyDick]

Nicotine without b-carbolines alkaloids is very weakly addictive.

 

 

http://www.ncbi.nlm....pubmed/15802796

 

Ok. It would prevent nAChRs desensitization but it might doesn't prevent downstream tolerance of nicotine. 

Galantamine rather doesn't prevent nicotine's downstream tolerance.