8 replies to this topic

[stefan_001]

Has anybody heard about this product? How it works? And if it works?

 

Collrepair DG: reverses 20 years of glycation in four months
Over time, consuming too much sugar can have a direct negative impact on the skin through a chemical reaction called glycation: slowly, glycation damages the structure of the skin. As a result, the skin loses its elasticity and resiliency, surface wrinkles appear, and skin tone is altered by a yellowing phenomenon. BASF’s new active ingredient Collrepair®DG, for the first time in cosmetics, is able to reverse the consequences of glycation: the synergistic complex breaks AGEs (Advanced Glycation End Products), and skin fibers gain back their flexibility and functionality. As a result, after four months of use, skin yellowing is reversed and skin firmness recovered, for a younger look.

 

https://www.basf.com...4/p-15-191.html

[aconita]

It is niacin and salvia miltiorrhiza (red sage) leaf extract. since it is water soluble I guess the red sage leaf extract is an hydro alcoholic extraction (ethanol/water 70%, since ethanol is much less toxic and irritating than methanol I tend to prefer it even if it might be slightly less effective), to be used up to 5% in a water base (hyaluronic acid gel, for example), not difficult at all to home made.

 

Salvia miltiorrhiza extracts are easy to buy but usually it is root or root-flower-leaf extract, probably not a big issue.

 

http://www.cossma.co...SFColRepair.pdf

 

http://www.sciencedi...278691510004102

 

 

[sthira]

^^*Do you use this as a topical?

[aconita]

Yes, it is for topical use, 5% in a water base serum, gel or cream. 

[stefan_001]

It is niacin and salvia miltiorrhiza (red sage) leaf extract. since it is water soluble I guess the red sage leaf extract is an hydro alcoholic extraction (ethanol/water 70%, since ethanol is much less toxic and irritating than methanol I tend to prefer it even if it might be slightly less effective), to be used up to 5% in a water base (hyaluronic acid gel, for example), not difficult at all to home made.

 

Salvia miltiorrhiza extracts are easy to buy but usually it is root or root-flower-leaf extract, probably not a big issue.

 

http://www.cossma.co...SFColRepair.pdf

 

http://www.sciencedi...278691510004102

Thanks for sharing. I think I will try to make this. Hands are a good testing area. If any good comes I will let know.

[niner]

It is niacin and salvia miltiorrhiza (red sage) leaf extract. since it is water soluble I guess the red sage leaf extract is an hydro alcoholic extraction (ethanol/water 70%, since ethanol is much less toxic and irritating than methanol I tend to prefer it even if it might be slightly less effective), to be used up to 5% in a water base (hyaluronic acid gel, for example), not difficult at all to home made.
 
Salvia miltiorrhiza extracts are easy to buy but usually it is root or root-flower-leaf extract, probably not a big issue.
 
http://www.cossma.co...SFColRepair.pdf
 
http://www.sciencedi...278691510004102

 
Is it possible that this stuff can break glucosepane crosslinks?  In the first document linked by aconita, they talk about reducing the number of CML (carboxymethyl lysine) adducts.  I don't know how this relates to glucosepane.  The important info is on page 6, in which the product was compared to a placebo, and skin firmness was tested with a cutometer, leading to the following claim:
 

After one month of application, Collrepair™ DG at 5% shows the ability to improve by 6% the skin elastic recovery, which is significantly higher than placebo.

 

The data they show is a little screwy; the placebo actually made skin recovery worse, which seems wrong.  That calls the statistical significance into some question, but still an interesting result.

 

If anyone tries to replicate this, the formulation might be important.  They list the following materials, (including CAS numbers!)

 

Water (and) Niacin (and) Caprylyl Glycol (and) Hexylene Glycol (and) Xanthan Gum (and) Salvia Miltiorrhiza Leaf Extract

CAS#: 7732-18-5; 59-67-6; 1117-86-8; 107-41-5; 11138-66-2   (Source page)

If you are relatively young, you probably will not notice much change in your skin.
 

[aconita]

Interesting that of all the CAS provided codes none is for the Salvia Miltiorrhiza Leaf Extract...which is by far the main variable in the formulation, there is even a CAS number for water...

 

I agree that since the research is provided by the producer a grain of salt is a must, I am not convinced at all about the supposedly revolutionary effect of the formulation...niacinamide at 4% in a hyaluronic acid gel is quite pleasant in my yet relatively brief experience with it and well worth a try.

 

Adding a Salvia Miltiorrhiza Leaf Extract might be interesting to experiment with since not overly difficult or expensive but with realistic expectations.

[YOLF]

It is niacin and salvia miltiorrhiza (red sage) leaf extract. since it is water soluble I guess the red sage leaf extract is an hydro alcoholic extraction (ethanol/water 70%, since ethanol is much less toxic and irritating than methanol I tend to prefer it even if it might be slightly less effective), to be used up to 5% in a water base (hyaluronic acid gel, for example), not difficult at all to home made.

 

Salvia miltiorrhiza extracts are easy to buy but usually it is root or root-flower-leaf extract, probably not a big issue.

 

http://www.cossma.co...SFColRepair.pdf

 

http://www.sciencedi...278691510004102

So will swallowing this stuff work? Why has no one reported these effects from the root extracts? Maybe it's just something that's only in the leaves?

 

Interesting that of all the CAS provided codes none is for the Salvia Miltiorrhiza Leaf Extract...which is by far the main variable in the formulation, there is even a CAS number for water... 

 

I agree that since the research is provided by the producer a grain of salt is a must, I am not convinced at all about the supposedly revolutionary effect of the formulation...niacinamide at 4% in a hyaluronic acid gel is quite pleasant in my yet relatively brief experience with it and well worth a try.

 

Adding a Salvia Miltiorrhiza Leaf Extract might be interesting to experiment with since not overly difficult or expensive but with realistic expectations.

 

Let's get one of our labs to obtain some and try it out... that's what we do afterall.

Edited by YOLF, 22 August 2016 - 11:16 AM.

[aconita]

So will swallowing this stuff work? Why has no one reported these effects from the root extracts? Maybe it's just something that's only in the leaves?

 

Oral route is not necessarily better or leading to the same effects, actually oral means digestion with all the processes involved, liver doing its job included, many actives get broken down to not so effective or even to not very healthy metabolites, intestine absorption can pose another variable...

 

It is possible that leaves contain some unique actives too, it is quite common to have mostly the same but some peculiar actives differences between different plant parts (roots, leaves, fruits, flowers, seeds, stems, bark), stinging nettles leaves and roots, for example, are quite different in constituents and therefore action.

 

If Salvia Miltiorrhiza Leaf Extract is of a low enough molecular weight, as it seems given the effects on AGEs, it will reach the blood flow when applied topically leading to an eventual systemic action, maybe a penetration enhancer would optimize that further.