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Rejuvenating the Mitochondria: Google TechTalk by Matthew O'Connor (SENS)

mitochondria sens mitosens damage repair

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#1 s123

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Posted 16 December 2016 - 09:49 PM

This is a really nice lecture by Matthew O'Connor. LongeCity helped years ago to get this research started with a science grant. 



The research presented in this lecture was recently published in Nucleic Acid Research


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#2 jroseland

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Posted 21 December 2016 - 11:14 AM

Will give it a watch. Thanks!

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#3 tunt01

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Posted 21 December 2016 - 06:32 PM

Pretty neat.  It will be interesting to see where this research goes in 10-20 years.  Nice of Matthew to give a credit to Longecity for helping with funding early on.

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#4 alc

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Posted 22 December 2016 - 01:45 AM

@ time 15:10 he says:


"... there are only 13 protein coding genes in the mitochondria ..."


repeats the same thing around 30:20


(sens understanding ... )










Until recently, scientists believed the mitochondrial genome contained only 37 genes and, as a result,
it had been relatively unexplored as a focus of drug discovery efforts.
Research by CohBar founders and their academic collaborators revealed that the mitochondrial genome
has dozens of potential new genes that encode peptides.






and here:


" For decades, scientists thought they had a handle on the mitochondrial chromosome: 13 genes for proteins, two for rRNAs and 22 for tRNAs, all tightly packed with no introns. “That’s a lot to ask of one small DNA,” said Pinchas “Hassy” Cohen, a mitochondrial biologist at the University of Southern California (USC). “And yet, on top of that, it appears to contain small open reading frames that are hidden inside the other genes.”


Cohen has discovered dozens of genes for short peptides nestled within the known mitochondrial genes like tiny Russian dolls. In two recent papers, Cohen and colleagues described seven such genes, encoding peptides 16-38 amino acids long, with roles regulating metabolism and either promoting or quelling apoptosis"








unfortunately another red flag for the research that is done by sens ...

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