6 replies to this topic

[MightyMouse]

I know there's been talk about NAD here in the past, but I found this fresh article on the subject.

 

https://hms.harvard....mysteries-aging

 

What makes it very exciting for me that apparently they are moving to human trials soon, which doesn't happen that often in field of life extension. And these guys are Harvard, not a group of enthusiasts. Imo looks very promising, if this really works as suggested it would be a very powerful way of extending life- and healthspan in very near future, nearer that I would have ever thought.

 

I think it's a bit scary even... Imagine if this thing works and makes its way to drug stores. Either it won't be accessible to masses, which would create huge social tension, or it will be, which would create a population explosion. Getting a bit sidetracked by philosophy now...

 

Anyways, what do you guys think of the article?

Edited by MightyMouse, 30 March 2017 - 09:18 AM.

[MikeDC]

I know there's been talk about NAD here in the past, but I found this fresh article on the subject.

https://hms.harvard....mysteries-aging

What makes it very exciting for me that apparently they are moving to human trials soon, which doesn't happen that often in field of life extension. And these guys are Harvard, not a group of enthusiasts. Imo looks very promising, if this really works as suggested it would be a very powerful way of extending life- and healthspan in very near future, nearer that I would have ever thought.

I think it's a bit scary even... Imagine if this thing works and makes its way to drug stores. Either it won't be accessible to masses, which would create huge social tension, or it will be, which would create a population explosion. Getting a bit sidetracked by philosophy now...

Anyways, what do you guys think of the article?

NMN and Nicotinamide Riboside are almost equivalent. NMN changes to Nicotinamide Riboside before entering cell. Some human studies have already been completed and validated that Nicotinamide Riboside raises NAD+ effectively in humans.

Please read the Nicotinamide Riboside threads.

[MightyMouse]

Ok, will do... The article was written in a tone that implied these are novel findings so thats why I made the topic.

 

 

 

[adoado]

"To determine how the proteins interacted beyond the lab dish and in living organisms, the researchers treated young and old mice with the NAD precursor NMN, which makes up half of an NAD molecule. NAD is too large to cross the cell membrane, but NMN can easily slip across it. Once inside the cell, NMN binds to another NMN molecule to form NAD."
 

NMN and Nicotinamide Riboside are almost equivalent. NMN changes to Nicotinamide Riboside before entering cell. Some human studies have already been completed and validated that Nicotinamide Riboside raises NAD+ effectively in humans.

Please read the Nicotinamide Riboside threads.

Edited by Michael, 07 May 2017 - 09:37 PM.
trim quotes

[Florian E.]

 

"To determine how the proteins interacted beyond the lab dish and in living organisms, the researchers treated young and old mice with the NAD precursor NMN, which makes up half of an NAD molecule. NAD is too large to cross the cell membrane, but NMN can easily slip across it. Once inside the cell, NMN binds to another NMN molecule to form NAD."

 

 

Thanks you for pointing this out.

 

To what i've read so far the main advantage of NMN compared to NR is that

- it raises NAD+ levels more than NR

- it can also increase NAD+ in damaged cells which NR is unable to do in some cases

 

Right ?

[adoado]

Seems so, i ordered nmn from revgenetics but still did not receive, they have shortage, not shipped yet.

To what i've read so far the main advantage of NMN compared to NR is that
- it raises NAD+ levels more than NR
- it can also increase NAD+ in damaged cells which NR is unable to do in some cases
 
Right ?

Edited by Michael, 07 May 2017 - 09:36 PM.

[MikeDC]

 

 

"NAD is too large to cross the cell membrane, but NMN can easily slip across it. Once inside the cell, NMN binds to another NMN molecule to form NAD."

Thanks you for pointing this out.

To what i've read so far the main advantage of NMN compared to NR is that
- it raises NAD+ levels more than NR
- it can also increase NAD+ in damaged cells which NR is unable to do in some cases

Right ?

NMN and NR are almost the same. NMN converts to NR before entering the cell.

Edited by Michael, 07 May 2017 - 03:30 AM.