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The relationship between dietary macronutrients and hepatic telomere length in aging mice (2017)

telomere length mice macronutrient ratio protein restriction

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#1 Darryl

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Posted 19 October 2017 - 03:32 AM

The Charles Perkins Centre group analyzed telemere lengths of samples from their past study on macronutrient ratios on mice lifespan. It's in accord with with their lifepan work.


Gokarn et al, 2017. The relationship between dietary macronutrients and hepatic telomere length in aging miceJournals of Gerontology Series A: Biomedical Sciences and Medical Sciences, p.glx186.

Macronutrients and dietary energy influence aging, age-related health and lifespan. Reduction in telomere length has been proposed as one mechanism for aging. Therefore this study investigated the effects of varying ratios of dietary macronutrients and energy on telomere length in older adult mice. C57Bl/6 mice were fed ad libitum their entire life on one of 25 diets varying in protein, carbohydrates, fat and energy. Average telomere length ratio (ATLR) was measured by PCR in livers of a subset of 161 mice aged 15 months. There was a significant positive relationship between ATLR and carbohydrate intake and a negative relationship with protein intake, but no relationships with fat or energy intake. Analysis using the Geometric Framework and Generalized Additive Models confirmed that carbohydrate intake was positively associated with ATLR, while the longest ATLR was achieved by mice restricted to low protein, high carbohydrate diets. ATLR distribution across the diets was parallel to median lifespan results previously published. ATLR was associated with blood levels of some amino acids (asparagine, glutamate, taurine) but not with blood levels of fatty acids, hepatic mitochondrial function, or nutrient sensing pathways. In conclusion, mice on low protein, high carbohydrate diets have the longest hepatic telomeres and longest lifespan.


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Also tagged with one or more of these keywords: telomere length, mice, macronutrient ratio, protein restriction

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