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5 uM Resveratrol roughly doubles (!?) the length of telomeres in fibroblasts

resveratrol telomere sasp resveralogue stillbene

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#1 HaplogroupW

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Posted 08 November 2017 - 07:08 AM


I had only ever heard of resveratrol and stillbenes acting via SIRT1 activation. But this recent result shows impressive effects, including increased telomere length, of resveralogues duplicated in each of 3 lines of human fibroblast cells:

 

https://bmccellbiol....2860-017-0147-7

 

 

We found that cells treated with resveratrol or any of the novel resveralogues had telomeres that were 1.3–2.4 times longer than vehicle-only controls, compared with younger cells at PD25, which showed telomeres 2.6 times longer than untreated senescent cells (Fig. 5c).

 

 

Also, it shows that it rescued SASPs from the senescent state.

 

I wasn't paying attention through the whole resveratrol episode, which I've heard described as a debacle. Has it totally fallen out of favor?



#2 HaplogroupW

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Posted 08 November 2017 - 11:37 AM

Oops, logic failure. The referenced result doesn't show that telomeres got longer. Rather, they were longer than the control (untreated). Which means the telomeres got shorter more slowly than the control. The treated cells were still shorter than the young cells with a lower passage number. Although not by much.

 

I wish we could edit our posts here.


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#3 Believer

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Posted 09 November 2017 - 10:09 PM

Unless resveratrol stops cell division or prevents oxidation of telomeres, the only way it can prevent telomere shortening seems to be if it increases telomerase activity. However lots of chemicals do this mildly but as has been noticed, nothing on the market currently extends telomeres beyond shortening, they only reduce shortening.


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#4 Nate-2004

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Posted 10 November 2017 - 01:55 PM

See this post: http://www.longecity...very-on-ageing/



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#5 Logic

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Posted 28 November 2017 - 02:18 PM

Unless resveratrol stops cell division or prevents oxidation of telomeres, the only way it can prevent telomere shortening seems to be if it increases telomerase activity. However lots of chemicals do this mildly but as has been noticed, nothing on the market currently extends telomeres beyond shortening, they only reduce shortening.

Yes they do.
Astragalus, and Purslane (probably growing as a weed between the paving stones in your garden) come to mind.

But was is more telling IMHO is that some cells express telomerase more than others do.
Cells like stem and progenitor cells express more.
Now; aren't those just the very cell types we would want to express more telomerase in...?  :)

ie:  Mild telomerase activation in, say fibroblasts,  may well translate into a whole lot of telomerase activation in stem etc cells, if we're lucky.

NB that telomerase activation seems to be inversely proportional to systemic inflammation.
So a regimen of Lactoferrin to kill the inflammation from lipopolysaccharides originating in the gut might well be an effective telomerase activator.
Also worth noting is that very little Astragalus makes it through the gut lining, yet its effective.
Maybe because the Astragalus IS able to get at the stem and progenitor cells that become the barrier between you and a vast amount of ...'pro inflammatories'..?
 


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