11 replies to this topic

[baccheion]

Is allantoin safe for oral consumption? What amount would equivalent to what's present in comfrey root? Are the following good enough for oral consumption:

- https://www.amazon.c...r/dp/B00I2SU40I

- https://www.bulkacti....html?limit=100

Edited by baccheion, 23 January 2018 - 06:20 PM.

[Iuvenale]

I take this Soloray Comfree. It has allantoin, but it doesn't state the amount. https://www.amazon.c.../dp/B0002JI114 

[baccheion]

I take this Soloray Comfree. It has allantoin, but it doesn't state the amount. https://www.amazon.c.../dp/B0002JI114

404. How much do you take? What effects does it have on you?

[Iuvenale]

I take one capsule a day. I can't discern effects, but I am taking many, many other supplements at the same time.

[Deckah]

From what I've read, it seems that there's around 2-3% of allantoin in comfrey.

Which is around the same amount that is usually dissolved for topical applications (typically 1%).

Can't comment on oral consumption.

What are you wanting to use it for?

[baccheion]

From what I've read, it seems that there's around 2-3% of allantoin in comfrey.
Which is around the same amount that is usually dissolved for topical applications (typically 1%).

Can't comment on oral consumption.

What are you wanting to use it for?

How many milligrams of allantoin powder does that suggest should be taken?

[Iuvenale]

I'm using it for the following (copied from my Notes app)

 

The compound exhibiting the highest similarity to metformin according to the metformin classifier (Fig. 2A) was allantoin, a key beneficial compound in yam (Dioscorea spp.). Like metformin, allantoin is a guanidinium derivative with anti-hyperglycemic effects [107,108]. It is an important metabolic intermediate of purine metabolism in many species across Eukarya and Bacteria domains [109,110]. Being a guanidinium derivative, allantoin is similar to metformin in structure and has been shown to induce glucose lowering effects via imidazoline I-2 receptors [107,108]. Other top hits for metformin included glucosamine, a compound used in the treatment of osteoarthritis [111,112], and cardamonin, a member of the anti-inflammatory chalcones found in plant-based foods [113

[to age or not to age]

I'm very interested in the combination of rapamycin, rifampicin and allantoin. In c elegans, it caused a 76% increase in maximum lifespan and actually doubled the median lifespan. The data indicated that the pathways affected by these three compounds are not narrowly overlapping.  My instinct tells me this is a big deal 

partly  because it's an available intervention, and, doubling the lifespan of c elegans through changing a gene is a different thing than simply combining three compounds, two of which (rapamycin and rifampicin are already used to treat medical conditions. Any ideas? 

Edited by to age or not to age, 07 March 2018 - 07:22 PM.

[micro2000]

Allantoin has really poor bioavailability.

[baccheion]

So, what's a good amount to take? I have the powder (linked to in original post), but I'm not sure how much to take (or if the powder is even safe for consumption).

[Iuvenale]

When I searched Pubmed for clinical trials on allantoin, there were no trials with oral allantoin. I also searched on "allantoin absorption" and didn't get anything relevant. Micro2000, why do you think it has poor absorption?

 

I guess we're all feeling around in the dark on this one.

[micro2000]

I remember looking into allantoin a while back and finding out it had poor oral bioavailability. I can't find the papers I read, but this one states that it has low bioavailability and investigates cyclodextrins as a method to enhance delivery.

https://www.ncbi.nlm...bioavailability