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February 2021 Longevity Review

Posted by Chris Pollyanna , 28 March 2021 · 1,498 views

supplements nmn fisetin curcumin resveratrol senolytics

Hello and welcome again to this month’s (delayed) longevity review. It turns out that slicing off a chunk of your right index finger is not a good idea. Who knew? Finally been able to touch type & use a pen again the past week.
Keeping the intro brief so that I can get this out before the end of the month, suffice to say that perhaps what will be the most important news to come out this year was announced by the NIA in February - check out the Round-Up for details.
A reminder that I have set up a Patreon account at the behest of a reader. Anyone wishing to buy me a cup of coffee is greatly appreciated! As an extra bonus, every month I’ll send you a PDF of all the studies which didn’t quite make the cut for this newsletter. There are still a lot of gems to be found! You can see a free example on Patreon.
Follow me on Twitter @ChrisPollyanna1 for the latest updates.
I hope you will also join my longevity Facebook group.
Stay safe!
**Once again this post has been cut-off due to space constraints - the full, unabridged version can be found at https://www.facebook...005813397/files or directly to your inbox if you subscribe at my Patreon account**
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Round-Up:
Starting off with some incredibly important news: the National Institute of Aging in the USA is for the first time soliciting grant proposals to test longevity therapies in humans! The significance cannot be overstated as too many potential treatments have been languishing in animal models for want of funding and official support. Although only $4.5 million is allocated and the earliest the selected trials can begin is April 2022, this could mark a phase change in finally getting proven results in humans.
The NIA Is Funding Clinical Trials Against Aging

 

Continuing the positive news, a paper came out showing that there has been exponential growth in the number of treatments which can extend lifespan in model organisms (over 2000 now), as well as the number of companies trying to bring them to market. Although the original paper is behind a paywall, here is a summary and interview with the author.
Longevity Pharmacology has Come of Age
Longevity Pharmacology with Dr. João Pedro de Magalhães

 

This opinion piece is a full throated declaration in support of extending lifespan and is also a nice concise overview of the substances which can do so in mammals.
The goal of geroscience is life extension Full Text

 

Good news for the wine lovers out there, this study involved flies and some lucky French nuns, who got the chance to have a couple glasses of red wine everyday with meals.
*Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster Full Text

 

Here, two molecules I’ve been closely following, J147 & CMS121, derived from Curcumin & Fisetin respectively, have also been shown to extend fly lifespans as well as improving brain and kidney function in mice.
Geroprotective effects of Alzheimer's disease drug candidates Full Text

 

Finally, for the follically challenged among you, CASIN, a molecule discovered to increase lifespan in mice last year, was also shown to rejuvenate hair stem cells.
A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells Full Text

 

Covid-19 Longevity Related Papers:

 

COVID-19, cytokines, inflammation, and spices: How are they related? Full Text
Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19 Full Text
Pineal hormone melatonin as an adjuvant treatment for COVID‑19 (Review) Full Text
Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity Full Text
The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19 Full Text
Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders Full Text

 

Videos to watch & Audio to listen to:
The International Longevity Alliance held an online conference on longevity therapies and moving them into people, with a number of interesting talks:
International Longevity Alliance Conference: Clarifying whether and to what degree the current anti-aging approaches work in mice or people

 

Peter Attia’s popular podcast had a great interview with Richard Miller of the ITP:
Richard Miller - The gold standard for testing longevity drugs: the Interventions Testing Program
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Supplemental Information

***Disclaimer 1 – As should be self-evident to anyone receiving these emails, I am NOT a doctor or indeed a scientist. All the information pertained within is for information purposes only; use at your own risk. Please consult with a healthcare practitioner if needing medical advice.***
**Disclaimer 2 – In no way should supplements be a replacement for an unhealthy diet or lifestyle. A varied, plant dominant dietary pattern is the cornerstone for health. Try to eat the rainbow – the greater the variety, the greater the benefit. Even though I might take a supplement derived from a plant source, I still eat the plant in question. Also, make sure you move as much as possible – that is what we evolved to do.**
*Also bear in mind that most of the studies mentioned below are in rodents, not humans. Rodents, needless to say, do not always react the same way to drugs as humans do – witness the countless times cancer or another disease has been cured in rodents only to subsequently fail human trials. I have *bolded any human trials.*
Lifestyle
Fasting/Dietary Restriction
*Five Days Periodic Fasting Elevates Levels of Longevity Related Christensenella and Sirtuin Expression in Humans Full Text
Two-meal caloric restriction induces 12-hour rhythms and improves glucose homeostasis Full Text
The Age-Sensitive Efficacy of Calorie Restriction on Mitochondrial Biogenesis and mtDNA Damage in Rat Liver Full Text

 

Diet
*Health Benefits of Plant-Based Nutrition: Focus on Beans in Cardiometabolic Diseases Full Text
*Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial Full Text
*Nuts and Older Adults' Health: A Narrative Review Full Text

 

Exercise
*Responses to Maximal Strength Training in Different Age and Gender Groups Full Text
*The association of objectively measured physical activity and sedentary behavior with skeletal muscle strength and muscle power in older adults: a systematic review and meta-analysis Full Text
*Effects of exercise-induced beta-hydroxybutyrate on muscle function and cognitive function Full Text

 

Non-prescription Supplements (in alphabetical order)

 

Astaxanthin
Nrf2 a molecular therapeutic target for Astaxanthin Full Text
Chronic Infusion of Astaxanthin Into Hypothalamic Paraventricular Nucleus Modulates Cytokines and Attenuates the Renin-Angiotensin System in Spontaneously Hypertensive Rats
Ameliorative effects of astaxanthin on brain tissues of alzheimer's disease-like model: cross talk between neuronal-specific microRNA-124 and related pathways

 

Curcumin
*The effects of nanocurcumin supplementation on inflammation in hemodialysis patients: A randomized controlled trial
*The Effect of Curcumin Supplementation on Anthropometric Measures among Overweight or Obese Adults Full Text
*Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis Full Text

 

Fisetin
Neuroprotective Effect of Fisetin Against the Cerebral Ischemia-Reperfusion Damage via Suppression of Oxidative Stress and Inflammatory Parameters Full Text
Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment Full Text

 

Melatonin
*Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease Full Text
*The Effect of Melatonin on Periodontitis Full Text
*Effect of Locally Delivered Melatonin as an Adjunct to Nonsurgical Therapy on GCF Antioxidant Capacity and MMP-9 in Stage II Periodontitis Patients: A Randomized Controlled Clinical Trial Full Text

 

Nicotinamide MonoNucleotide (NMN)
Safety evaluation after acute and sub-chronic oral administration of high purity Nicotinamide mononucleotide (NMN-C®) in Sprague-Dawley rats Full Text
Nicotinamide Mononucleotide Restores the Meiotic Competency of Porcine Oocytes Exposed to Ethylene Glycol Butyl Ether Full Text
Nicotinamide Mononucleotide Alleviates Hyperosmolarity-Induced IL-17a Secretion and Macrophage Activation in Corneal Epithelial Cells/Macrophage Co-Culture System Full Text

 

Nicotinamide Riboside (NR)
*Nicotinamide riboside enhances in vitro beta-adrenergic brown adipose tissue activity in humans
*NAD +-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin Full Text
Basic nutritional investigationShort-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors

 

Pterostilbene
Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of Sirtuin 1
Pterostilbene accelerates wound healing by modulating diabetes-induced estrogen receptor β suppression in hematopoietic stem cells Full Text
Pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K/Akt pathway Full Text

 

Resveratrol
*The effects of resveratrol supplementation on PPARα, p16, p53, p21 gene expressions, and sCD163/sTWEAK ratio in patients with type 2 diabetes mellitus: A double-blind controlled randomized trial
*Effect of resveratrol on menstrual cyclicity, hyperandrogenism and metabolic profile in women with PCOS
Resveratrol protects against myocardial ischemic injury via the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses Full Text

 

Spermidine
Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine Full Text
Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome Full Text
Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway Full Text

 

Other available supplements (in alphabetical order)
*Aspirin Use on Incident Dementia and Mild Cognitive Decline: A Systematic Review and Meta-Analysis Full Text
*The Neurocognitive Effects of Bacopa monnieri and Cognitive Training on Markers of Brain Microstructure in Healthy Older Adults Full Text
*The joint effect of energy reduction with calcium supplementation on the risk factors of type 2 diabetes in the overweight population: a two-year randomized controlled trial Full Text
*Current Evidence and Possible Future Applications of Creatine Supplementation for Older Adults Full Text
*Creatine Supplementation and Brain Health Full Text
*Positive effects of folic acid supplementation on cognitive aging are dependent on ω-3 fatty acid status: a post hoc analysis of the FACIT trial
*Effects of Red and White Ginseng Preparations on Electrical Activity of the Brain in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled, Three-Armed Cross-Over Study Full Text
*Strawberry (Fragaria ananassa duch.) Alba extract attenuates DNA damage in lymphocytes of patients with Alzheimer's disease
*Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women
*Effects of testosterone treatment, with and without exercise training, on ambulatory blood pressure in middle-aged and older men
*Testosterone replacement in aging men: an evidence-based patient-centric perspective Full Text

 

Prescription Supplements

 

Metformin
*Metformin use and respiratory outcomes in asthma-COPD overlap Full Text
*The effect of the anti-diabetic drug metformin on musculoskeletal pain: a cross-sectional study with 21,889 individuals from the UK Biobank
The Current and Potential Therapeutic Use of Metformin-The Good Old Drug Full Text

 

Rapamycin (sirolimus)
*Intravitreal sirolimus for persistent, exudative age-related macular degeneration: a Pilot Study Full Text
*Rapamycin is Effective for Upper but not for Lower Gastrointestinal Crohn's Disease-Related Stricture: A Pilot Study Full Text
Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy Full Text

 

Other Areas of Interest (in alphabetical order)

 

Ageing Clocks & other biomarkers of ageing
*An integrative study of five biological clocks in somatic and mental health Full Text
*Data-driven identification of ageing-related diseases from electronic health records Full Text
Tissue-Specific Landscape of Metabolic Dysregulation during Ageing Full Text

 

Blood/Plasma Factors
*Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age Full Text
Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise Full Text
Plasma osteopontin as a biomarker of Alzheimer's disease and vascular cognitive impairment Full Text

 

Epigenetics & Cellular Reprogramming
*Epigenetic Age Acceleration and Cognitive Decline: A Twin Study
Aging and rejuvenation - a modular epigenome model Full Text
Association of cardiovascular health and epigenetic age acceleration Full Text

 

Exosomes (small packets of information released by cells)
Extracellular Vesicles and Exosomes: Insights From Exercise Science Full Text
Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis Full Text
Transfer of lncRNA UCA1 by hUCMSCs-derived exosomes protects against hypoxia/reoxygenation injury through impairing miR-143-targeted degradation of Bcl-2 Full Text

 

Genetics including CRISPR
CRISPR/Cas9-mediated CysLT1R deletion reverses synaptic failure, amyloidosis and cognitive impairment in APP/PS1 mice Full Text
Transposable element landscape in Drosophila populations selected for longevity Full Text
Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissues Full Text

 

Lifespan Lengthening Interventions
Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies Full Text
Sodium rutin extends lifespan and health span in mice including positive impacts on liver health
A glucose-supplemented diet enhances gut barrier integrity in Drosophila Full Text
Green light extends Drosophila longevity
Effect of citrus peels-supplemented diet on longevity, memory index, redox status, cholinergic and monoaminergic enzymes in Drosophila melanogaster model
Xanthohumol prolongs lifespan and decreases stress-induced mortality in Drosophila melanogaster
Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling Full Text
Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans Full Text
Enhanced Healthspan in Caenorhabditis elegans Treated With Extracts From the Traditional Chinese Medicine Plants Cuscuta chinensis Lam. and Eucommia ulmoides Oliv Full Text

 

Microbiome
*Gut microbiome implicated in healthy aging and longevity Full Text
*Changes in Gastric Corpus Microbiota With Age and After Helicobacter pylori Eradication: A Long-Term Follow-Up Study Full Text
Lactobacillus plantarum 69-2 Combined with Galacto-Oligosaccharides Alleviates d-Galactose-Induced Aging by Regulating the AMPK/SIRT1 Signaling Pathway and Gut Microbiota in Mice

 

Miscellaneous Molecules
*Methylphenidate for Mild Cognitive Impairment: An Exploratory 3-Day, Randomized, Double-Blind, Placebo-Controlled Trial Full Text
MOTS-c reduces myostatin and muscle atrophy signaling
GDF11 alleviates secondary brain injury after intracerebral hemorrhage via attenuating mitochondrial dynamic abnormality and dysfunction Full Text
Neuroprotective effect of hydrogen sulfide against glutamate-induced oxidative stress is mediated via the p53/glutaminase 2 pathway after traumatic brain injury Full Text
Protective effects of a mitochondria-targeted small peptide SS31 against hyperglycemia-induced mitochondrial abnormalities in the liver tissues of diabetic mice, Tallyho/JngJ mice
The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro
Oxytocin promotes hepatic regeneration in elderly mice Full Text
An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure Full Text

 

Observational Studies
*Herpesvirus infections, antiviral treatment, and the risk of dementia-a registry-based cohort study in Sweden Full Text
*Ambient PM 2.5 species and ultrafine particle exposure and their differential metabolomic signatures Full Text
*Analysis of the levels of inflammatory parameters in persons over the age of 90 Full Text

 

Opinion/Editorials/Theory
Beyond genes and environment, random variations play important role in longevity Full Text
DNA- and telomere-damage does not limit lifespan: evidence from rapamycin Full Text
The COVID-19 Pandemic, Biogerontology and the Ageing of Humanity Full Text PDF

 

Reviews
Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure Full Text
Role of NAD + in regulating cellular and metabolic signaling pathways Full Text
Mechanistic new insights of flavonols on neurodegenerative diseases Full Text

 

Senolytics/Senescent Cells
Senolytics for Cancer Therapy: Is All That Glitters Really Gold? Full Text
[size=4][font=arial]Senescent cells and the incidence of age-related diseases[color=rgb(0,0,0)][

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