May 2021 Longevity Review

Posted by Chris Pollyanna , 11 June 2021 · 1,321 views

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Hello and welcome again to this month’s longevity review. By far the most important longevity news this past month was the launch of the PEARL crowdfunding campaign, which seeks to test Rapamycin in humans. Rapamycin was the first drug proven to extend the lifespan of mammals, as well as improving their general health. However, we need to find out if the same applies to humans, which is exactly what this crowdfunding campaign will find out. That’s why I think this is the world’s most important clinical trial. What other drug could potentially cut your risk of getting Alzheimer’s, cancer and heart disease at the same time? And did I mention it could also improve vaccine response by strengthening the immune system?

So please, whatever your financial position, consider donating towards this groundbreaking campaign! They have already reached their initial and first stretch goal, but if their final stretch goal is reached, then they can run even more tests and find out even more useful information.

PEARL: PARTICIPATORY EVALUATION OF AGING WITH RAPAMYCIN FOR LONGEVITY

Follow me on Twitter @ChrisPollyanna1 for the latest updates.

The Canadian Longevity Association website continues to grow with the addition of a News page.
For previous Longevity Reviews, they can be found on the Canadian Longevity Association Facebook group, which I hope you will also join.
A reminder that you can show your support via my Patreon account, which includes bonus material for members.

Stay safe!
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Round-Up:

Time restricted eating is a form of fasting where your daily calories are consumed within a certain window, typically between 6 - 12 hours. The health effects in mice are remarkable, and now studies such as this are starting to show similar benefits in humans. Here, combined with exercise, it led to reduced fat and increased muscle mass.
*Time-restricted eating and concurrent exercise training reduces fat mass and increases lean mass in overweight and obese adults Full Text

Partial epigenetic reprogramming is the next big thing in longevity research and the number of studies are finally starting to increase. Here, the technique was used to improve muscle regeneration.
How to boost muscle regeneration and rebuild tissue Full Text

Stem cells continue to attract interest for their therapeutic potential, but it is becoming increasingly clear that the molecules they release are even more interesting. Here, their extracellular vesicles are shown to improve degenerative disc disease in mice.
Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration Full Text

New ways to remove senescent cells continue to be found. In this study, researchers were able to induce natural killer T cells to clear out senescent cells, which resulted in improved glycemic control and lung fibrosis.
Scientists find mechanism that eliminates senescent cells Full Text

Covid-19 Longevity Related Paper:
Curcumin as a Potential Treatment for COVID-19 Full Text
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Videos to watch:
Another YouTube channel with interviews with leading longevity researchers:

Foresight Institute - Biotech & Health Extension Focus
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Further sources of information:
Fight Aging! (quite opinionated about the damage theory of ageing)
Life Extension Advocacy Foundation (LEAF)/Lifespan.io (best source of longevity information on the web & I volunteer for them)

Research Institutes:
SENS Research Foundation
Buck Institute

Private initiatives:
Age-Reversal Network (good information & forums for those interested in self-experimentation – this is where I found how to get non-prescription Rapamycin)
Better Humans
Gerontology Research Group

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2021 Supplemental Information

***Disclaimer 1 – As should be self-evident to anyone receiving these emails, I am NOT a doctor or indeed a scientist. All the information pertained within is for information purposes only; use at your own risk. Please consult with a healthcare practitioner if you need medical advice.***

**Disclaimer 2 – In no way should supplements be a replacement for an unhealthy diet or lifestyle. A varied, plant dominant dietary pattern is the cornerstone for health. Try to eat the rainbow – the greater the variety, the greater the benefit. Even though I might take a supplement derived from a plant source, I still eat the plant in question. Also, make sure you move as much as possible – that is what we evolved to do.**

*Also bear in mind that most of the studies mentioned below are in rodents, not humans. Rodents, needless to say, do not always react the same way to drugs as humans do – witness the countless times cancer or another disease has been cured in rodents only to subsequently fail human trials. I have *bolded any human trials.*
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Lifestyle
Fasting/Dietary Restriction – certainly the cheapest & also one of the most effective anti-ageing interventions currently available. It comes in many flavours, but I fast for at least 12 hours every day.
*Effects of intermittent (5:2) or continuous energy restriction on basal and postprandial metabolism: a randomised study in normal-weight, young participants Full Text
*The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus Full Text

Diet – let food be thy medicine…
*One cup of leafy green vegetables a day lowers risk of heart disease Full Text
*The role of diet quality and dietary patterns in predicting muscle mass and function in men over a 15-year period Full Text
*Adherence to dietary guidelines and cognitive decline from middle age: the Doetinchem Cohort Study Full Text

Exercise – if you could bottle the benefits of exercise, it would be the biggest blockbuster drug of all time.
*Effects of exercise on cellular and tissue aging Full Text
*Light-Intensity Physical Activity and Life Expectancy: National Health and Nutrition Survey
*Different physical activity 'cocktails' have similar health benefits Full Text

Non-prescription Supplements (in alphabetical order)
*Due to concerns about engendering homeostasis, I’ve begun varying my intake of supplements so that I’m not taking all of them every day. Haven’t worked out a rota so far.

Astaxanthin – which is behind the pink colour of salmon & shrimp. Considered the most powerful carotenoid, it has anti-oxidative, anti-inflammatory, anti-cancer, neuro-protective and skin-protective qualities. I take 4 or 8 mg intermittently.
Effects of astaxanthin in animal models of obesity-associated diseases: A systematic review and meta-analysis
Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches

Curcumin – the spice which gives curries their yellow colour. Anti-inflammatory and neuroprotective. I take 1 gram intermittently. Needs to be taken with black pepper (piperine) to improve bioavailability.
*The Effects of Curcumin on Diabetes Mellitus: A Systematic Review Full Text
*A Systematic Review Assessing Clinical Utility of Curcumin with a Focus on Cancer Prevention Full Text
*The efficacy and safety of Curcuma longa Extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis Full Text

Fisetin – a flavonoid found in highest concentrations in strawberries. Senolytic, anti-inflammatory, anti-cancer, neuro-protective & Sirt1 activator. I take 100mg intermittently.
Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway

Melatonin – a natural hormone produced in the pineal gland, it makes us get to sleep every night, but it has many other functions, including as a mitochondrial antioxidant. I take 3mg every night primarily as a sleep aid.
*Melatonin and Cardioprotection in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
*Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: a systematic review and meta-analysis of randomized controlled trials Full Text
*Melatonin and the health of menopausal women: a systematic review Full Text