Has anyone tried this, maybe for other reasons? Essentially what I want to know about is experiences with mild baclofen withdrawal for people who have ADHDish problems.
I only have had this idea because I have a *huge* amount of experience with GHB withdrawal in any shape or form, and I believe that a fair share of it is very beneficial to my situation, but in a milder fashion. In a way that I have been experiencing up until maybe 5-6 years off the drug. I feel, like with any other drug, that the neurological withdrawal effects never truly went away 100% but only logarithmically decreased. Because I used such extreme amounts this translated to years of minor after-effects. I have actually used GHB from day zero in the fashion of experiencing on/off benefits, caused by basically either targeted depression or stimulation of the nervous system, if needed, that cancel each other out at average. It was only after I took too much and got so addicted that I just increased and increased the dosage, not experiencing any benefits anymore from it at all but only intoxication.
If you do not know this: GHB acts on the GHB receptor (which affects a vast array of neurotransmitters all over the place). But the higher you increase the dosage, the more dramatic GHB will have affinity to GABA-B, just like baclofen, and GABA-B will also partially suppress the effects that are mediated by the GHB receptor. This mechanism is also poorly accounted for in related research and should be kept in mind. GABA-B is what almost exclusively causes the "serious" GHB withdrawal effects like hypertension, agitation and anxiety. It is not clear from literature if baclofen does also cancel the possible psychotic/hallucinogenic effects of GHB withdrawal. But my theory is that those are not caused by GABA-B itself, but only amplified through it. GHB withdrawal will also trigger dysphoria/depression, but obviously this is due to GHB not GABA-B.
I could pull up all sorts of untelling research on how GABA-B is related to dopamine suppression or what not but there is no point, google it yourself. I have experienced this and basically it is just about creating some sort of sustainable, non-addictive nervous system upregulation that doesn't cause withdrawal effects which last for years, doesn't cause confusion, physical side-effects, catecholamine overload, etc and just "works" in a way you can mostly make sense of in terms of life-management and concentration, if you have the sort of ADHD-related lack of alertness I have.
If you are super-prone to seizures muscle cramps and what not baclofen is used against, then obviously this method would suck for you. But I am not, like most other people. Also I would say upregulating the nervous system in this very general manner, is disadvantageous to disporders like schizophrenic psychosis or even autism, even more than what you get through amphetamines or nicotine. There is a huge safe-range between the extremes of GABA-B tolerance people get through GHB withdrawal and what you will still possibly benefit from when inducing it with baclofen. Baclofen has virtually no addiction potential for all I know. The effect will not be especially pleasant or unpleasant thus the withdrawal won't be either. Of course the more you derail any neurotransmitter in your head, the more it will eventually just lead to dysfunction and anxiety effects. But the goal is to get it just right.
So I am considering this:
To take large amounts of baclofen every night before sleep that really put me out for a minimum of 1-2 weeks. Then I just take less or more depending on how I feel during the day. It shouldn't affect sleep quality much, just like GHB does not. It has a short half-life, so 8 hours later you only have 5-20% of it in your system, thus a fair share of the day you will basically be in a neurological withdrawal mode from the drug. If you discontinue the drug the withdrawal will just subside (and thus the desired effect). It is not like it will linger around with you for years.
Very related:
http://www.marketwat...epsy-2014-05-07
What do you think? Experiences?
Edited by Aolministrator, 25 January 2015 - 09:44 AM.