Guys, please help me figure out why venlafaxine and other drugs almost stopped working. The most important for me is that venlafaxine doesn't work like it should. Now it acts like when I take high dose - it's sedating, like too much serotonin.
But let's start from the beginning. Reminder - I am that guy with brain changes who suffer from mainly negative symptoms without any positive. Venlafaxine was helping me.
Then, at the beginning of 2017 I experienced first panic attack. Very short which is unusual - panic attacks are longer. My physical health started to getting worse. Psoriasis and tachycardia showed up. I got beta blockers and benzodiazepine. My thyroid hormones were slighly elevated but the cause was the meds. Now my thyroid is normal but ultrasound showed changes similar to Hashimoto's. My doc said that if my lab results are normal then she will not treat it. Anyway, I was feeling fatigued all the time but venlafaxine was still working. Months passed and I started experience gastric symptoms and the brain fog showed up. Got IBS diagnosis. And I think at that moment I noticed that all my meds are not working as efficient as they should. For 1-2 months they stopped completely working. Now venlafaxine works but it works like I wrote before. I don't know what's happening. I am waiting for gastroscopy because there's suspicion that I might have Celiac disease. I had couple of neurological symptoms of this illness as nystagmus and gait disturbances. Psoriasis is one of the symptom. Another possible cause is my tooth infection. AFAIK when tooth is infected for long period of time, it can fuck up the whole body. IBS can be linked to oral health. IBS can fuck up med absorption. My teeth is in treatment stage, antibiotic has been applied inside of it. Can anyone give me a tip why the hell venlafaxine and even duloxetine doesn't work like it should?
Because there's no diagnosis made yet (the brain changes), the physical part of it is just another "illness". My brain changes: atrophied cerebellum (got better), atrophied grey matter, enlarged prefrontal space, SPECT: hypoperfusion in right frontal lobe and asymmetric activity.
I will check my cortisol and ACTH levels because I am no longer numb to stress. I even can't tolerate it. Even slight stressor can make my cheeks red, hands cold, increase heart reate, sweating and adrenaline rush sometimes. I still feel uptight so I want to check if my adrenals are ok. Funny thing is that my GP said I have anxiety disorder but psychiatrist denied.
Thanks.