After trying many drugs I decided to look into the science of anxiety, well I don't pretend like I am smart or anything and it was pretty easy for me to find that my anxiety was caused by the CRHR1 gene. When this receptor is activated it increases anxiety but too little of it also causes fear due to low dopamine in certain part of the brain, but it is always better to have less activity of this gene. Anyway, since there are no CRHR1 antagonist accessible on the market and the ones that have been made like Antalarmin or Pexacerfont are still not available to be prescribed by doctors and probably won't be anytime soon, I decided to find drugs that are already out that have different mechanisms but just happen to also influence the CRHR1 receptors.
To make a long story short, I come to the conclusion of two drugs, Olanzapine & Valproic Acid. They both affect CRHR1 receptors in the brain in different ways, the former drug inhibits stimulated CRH release (CRH is the ligand which activates CRHR1 receptors) in the hippocampus which reduces anxiety there and which causes indirect effects to other regions. The latter is more powerful, it reduces CRHR1 and affects many areas, Cortex /CRHR1 decrease binding) and Basal(decrease CRH) & Central amygdala(decrease CRH) and many other insignificant areas. And yes CRHR1 or CRH is the target. So I'm currently on 2000mg valproic acid and 20mg olanzapine and I can with confidence say I'm completely anxiety-free, so much that I feel like it is dangerous. What do I mean by that? well I feel like there has to be a healthy level amount of anxiety to keep you from doing stupid shit, but on this combo I feel like I can't feel danger and I end up doing some shit that puts me in bad situations. I don't know if it is cause I had anxiety for so long which has made me stronger so when the anxiety is gone I feel it more due to the strength that I got from the years of anxiety, hard to explain. If anyone has trouble with SA(social anxiety) try this combo it works great for me. I can compare it to stronger than xanax. Preferred a real CRF1 antagonist tho less side effects and work more efficient but this will do for now. Also other ligands can bind to CRHR1 lile urocortin etc so decreasing CRH is not 100% efficient you need something that decreases CRHR1 binding or something, but like I said this will do and it works.
Edited by farshad, 10 January 2019 - 07:00 PM.