100 grapes per day (5 grams per grape)? Maybe you are just happy from the gargantuan amounts of sugar contained in that many grapes.
Ive used over 100+ substances (both herb and pharma), I can feel when something is doing something. Also the effect suddenly 'pops up' T+1-3hours after eating them, which is in line with maximum concentration of resveratrol found in plasma in human studies.
Yeah Im aware of the amount of sugar (well fructose) in it, however drinking the same amount of carbs in the form of lemonade does nothing to me.
I do have mito dysfunction though and ADHD/ASD, theres tons of studies out there recently about resveratrol and ptero having an effect on innate immunity, inflammation and paravalbumin problems in ASD. Also resveratrol seems to enhance pCREB in the amygdala and PFC similar to SSRI's.
Btw I have used GSE (grape seed extract) and pycnogenol in the past and the effect was no way close to this.
Resveratrol suppresses neuroinflammation in the experimental paradigm of autism spectrum disorders.
https://www.ncbi.nlm...pubmed/28025035
Resveratrol Prevents Cellular and Behavioral Sensory Alterations in the Animal Model of Autism Induced by Valproic Acid.
https://www.ncbi.nlm...pubmed/29872390
"Our data showed for the first time an altered localization of PV+-neurons in primary sensory cortex and amygdala. We also showed a reduced level of gephyrin in the primary somatosensory area (PSSA) of VPA animals. The treatment with RSV prevented all the aforementioned alterations triggered by VPA. Our data shed light on the relevance of sensory component in ASD and highlights the interplay between RSV and VPA animal model as an important tool to investigate the pathophysiology of ASD."
Resveratrol ameliorates prenatal progestin exposure-induced autism-like behavior through ERβ activation
https://molecularaut...3229-018-0225-5
ERβ is needed for oxytocin transscription btw
Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex.
https://www.ncbi.nlm...pubmed/26801825
Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/β-Catenin Pathway
https://www.frontier...2016.00044/full
"RES-treated rats showed increased rearing frequency and distance in the open-field test, increased sucrose preference in the sucrose preference test, and decreased immobility in the forced swimming test compared with SCH rats."
Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats.
https://www.ncbi.nlm...pubmed/24503118
"All of these effects of resveratrol were essentially identical to that observed with the established antidepressant, desipramine. In conclusion, our study shows that resveratrol exerted antidepressant-like effects in CUMS rats, mediated in part by normalizing serum corticosterone levels while up-regulating pERK, pCREB and BDNF levels in the hippocampus and amygdala."
Also obviously resveratrol increases autophagy and inhibits mTOR which is considered extremely beneficial in ASD. Theres an endless amounts of studies backin up its anti-anhedonia effect btw on top of that theres more users reporting it on longecity. Im just surprised by the extremely small quantities of resveratrol must be in 500gram worth of grapes, I mean I can see how the supp can make me manic.
FYI Im subclinical hypothyroid (tsh antibodies, autoimmune and using levothyroxine for it).
Edited by MankindRising, 18 February 2019 - 06:39 PM.