Part of the lasting anhedonic or other side-effects by Risperidone and similar medications is hypothesized (e.g. wikipedia, or agonist/antagonist profile) to be actually caused by dopamine overexcitation in the mesolimbic system, rather than excess serotonin. I.e., its partial agonism of dopamine receptors, along with additional overcompensation by the body, might have caused the system to downregulate significantly afterwards or even incur damage (the same as with drug abuse).
I think I have already moderate success with going the opposite route in serotonin, i.e. giving the body serotonin by way of 5-HTP, rather than depriving it of it, whereas trying to boost dopamine usually doesn't even have temporary effects, but seems to cause simultaneous exhaustion with the onset of effects (like the system can't bear it, doesn't care for it). Though this varies slightly and from time to time, but without great encouragement.
Therefore I'd like to see what dopamine-antagonism in the mesolimbic area might do, or efficiently decreasing dopamine in there. I doubt this would be risky, except to cause temporary discomfort, but it seems a more likely route to try than conventionally grooming dopamine receptors and encouraging dopamine release.
At least that is the purpose of this thread.
What are supplements which might do that? Block dopamine in the mesolimbic system or decrease it? I vaguely have assocations with licorice root doing this, but I'm not sure, and can't think of anything else.
Edited by DaveX, 29 July 2019 - 03:41 PM.