I was going to take my TMG (trimethylglycine) today & wondered if it might be better with or without food. Looking at the label, I saw it said: "Methyl donors such as TMG and folate are required for (edit) and for accurate synthesis of DNA and RNA". RNA synthesis? Sounds like what's going on during coronavirus replication! I've also been taking SAM-e (another powerful methyl donor) & Methyl Folate; & while I expect you wouldn't want to intentionally restrict dietary folate, it may be unwise to to be flooding my body with multiple/potential coronavirus fertilizers.
I've heard acetaminophen (aka Tylenol / paracetamol) can badly deplete glutathione, which may greatly exacerbate the oxidative stress Dr Seheult (MedCram) opined is likely responsible for clotting & endothelial dysfunction in the lungs of COVID patients. I've often wondered if doctors are still recommending Tylenol for fever reduction in their COVID patients. Have also read dextromethorphan, a common cough suppressant might exacerbate a coronavirus infection, though I don't recall the mechanism.
In our Supplements & Therapies thread, we've discussed how blood pressure and cardiac meds are known to deplete zinc, & how this might be at least partly responsible for the morbidity associated with these conditions. For those who must stay on these meds, I should think zinc supplementation would be essential. In fact, all diuretics: ACEi, ARB's, thiazide meds, coffee, tea, alcohol, & the diuresis of diabetes are known to deplete both zinc and magnesium which is required for Vitamin-D activation.
PPI meds (proton pump inhibitors) are also known to predispose zinc deficiency, & I noticed the other day those on PPI meds have been found to be substantially more susceptible to SARS-CoV-2 infection.
I'm hoping other members will contribute any and all information they might have regarding supplements, medications and perhaps other factors that may exacerbate disease during a SARS-CoV-2 infection, and how unavoidable adverse interactions might be averted.