There are numerous of studies on resveratrol. Unfortunately almost all seem to be animal or cell studies with various limitations as noted in this summary:
http://lpi.oregonsta...ls/resveratrol/
So it would be interesting to see what human studies showing efficiency actually exist. Studies simply studying the metabolism of resveratrol, epidemiologic studies, or resveratrol + something else are not that interesting.
Here is what I can find:
Sirtris has two studies showing that "SRT501, a SIRT1 activator, is our proprietary formulation of resveratrol with improved bioavailability SRT501was found to be safe and well tolerated in two Phase IIa clinical studies in patients with Type 2 Diabetes. In the second Phase IIa trial, Type 2 Diabetic patients were given 1.25 or 2.5 grams of SRT501 orally twice daily for 28 days. The patient group receiving 2.5 grams twice a day had significantly lower blood glucose levels as determined through an oral glucose tolerance test on day 28 at the test’s two-hour time point, as compared to the placebo group. At 2.5 grams twice daily, the study also found that SRT501 had a statistically significant lowering of both fasting blood glucose and glucose levels after meals, known as the postprandial period, an important timeframe for patients with Type 2 Diabetes who need better control of blood sugar levels after eating."
http://www.sirtrisph...news-press.html
http://www.sirtrisph...m/pipeline.html
http://www.medicalne...cles/104564.php
1.25 g x 2 of this formulation did not affect glucose significantly. Still not clear if it affects Hba1c or the clinical course of the disease itself.
But surely there are more? Please list any others.