High: Arginine Vasopressin, Cortisol, Choline, Dynorphin (<- may be a consequence of high cortisol + Arginine Vasopressin)
Low: Monoamines (Serotonin, Dopamine, Norepinephrine), Neurotrophins (BDNF, NGF), Anandamide (may be related to low Omega 3), Inositol
Complex: Glutamate, GABA, Hormones (depending on gender), Immune system (opposing studies), Other neuropeptides ie. everything affected by 'prolyl endopeptidase' (conflicting studies)
Therefore, if you're taking a classic antidepressant, and you ain't getting a sufficient response, these other factors may be the reason why.
Supplements/substances which target these other factors are listed below:
High cortisol - Theanine, Ashwagandha, Rhodiola, DHEA (safe?), Mirtazapine (a medication which is perhaps the most potent)
High AVP - Alisma orientalis, Californian Poppy
Dynorphin - Amentoflavone (found in Ginkgo Biloba or St John's Wort [watch out for Serotonin Syndrome])
Choline - stay away from pro-choline supplements (Huperzine A, Citicholine, Alpha GPC)
Low neurotrophins - Theanine, Lion's Mane
Anandamide - Omega fatty acids, Cocoa, Maca (?)
Inostiol - Inositol
Fascinatingly, look at someone with antisocial personality disorder, or psychopathy, and you effectively have a reverse case scenario of all of the above.
Edited by agwoodliffe, 06 April 2014 - 12:23 AM.