From what I've read it seems that uridine is just a substrate in reaction to build cdp choline or am I wrong ?
can I use cdp choline instead of uridine in uridine/dha/choline combo
Started by
somethingstrange
, Aug 01 2014 01:14 PM
cdp choline uridine
1 reply to this topic
#1
Posted 01 August 2014 - 01:14 PM
#2
Posted 02 December 2014 - 12:53 PM
I was wondering the same thing.
http://wurtmanlab.mi...tic/pdf/972.pdf
ABSTRACT. Twelve mildly hypertensive but otherwise normal fasting subjects received each of four
treatments in random order: CDP-choline (citicoline; 500, 2000, and 4000 mg) or a placebo orally at 8:00 a.m.on four different treatment days. Eleven plasma samples from each subject, obtained just prior to treatment (8:00a.m.) and 1–12 hr thereafter, were assayed for choline, cytidine, and uridine. Fasting terminated at noon withconsumption of a light lunch that contained about 100 mg choline. Plasma choline exhibited dose-relatedincreases in peak values and areas under the curves (AUCs), remaining significantly elevated, after each of thethree doses, for 5, 8, and 10 hr, respectively. Plasma uridine was elevated significantly for 5–6 hr after all threedoses, increasing by as much as 70–90% after the 500 mg dose, and by 100–120% after the 2000 mg dose. Nofurther increase was noted when the dose was raised from 2000 to 4000 mg. Plasma cytidine was not reliablydetectable, since it was less than twice blank, or less than 100 nM, at all of the doses. Uridine is known to enterthe brain and to be converted to UTP; moreover, we found that uridine was converted directly to CTP inneuron-derived PC-12 cells. Hence, it seems likely that the circulating substrates through which oral citicolineincreases membrane phosphatide synthesis in the brains of humans involve uridine and choline, and not cytidineand choline as in rats.
Edited by William Sterog, 02 December 2014 - 12:54 PM.
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